CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway
Our previous study demonstrated that CopA3, a disulfide dimerof the coprisin peptide analogue (LLCIALRKK), has antibacterialactivity. In this study, we assessed whether CopA3caused cellular toxicity in various mammalian cell lines.CopA3 selectively caused a marked decrease in cell viabilityin Jurkat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Biochemistry and Molecular Biology
2012-02-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0yJTVEMTIwMjI3MTA0NV8lMjgwODUtMDkwJTI5Qk1CMTEtMTI2LnBkZg== |
| Summary: | Our previous study demonstrated that CopA3, a disulfide dimerof the coprisin peptide analogue (LLCIALRKK), has antibacterialactivity. In this study, we assessed whether CopA3caused cellular toxicity in various mammalian cell lines.CopA3 selectively caused a marked decrease in cell viabilityin Jurkat T, U937, and AML-2 cells (human leukemia cells),but was not cytotoxic to Caki or Hela cells. Fragmentation ofDNA, a marker of apoptosis, was also confirmed in the leukemiacell lines, but not in the other cells. CopA3-induced apoptosisin leukemia cells was mediated by apoptosis inducingfactor (AIF), indicating induction of a caspase-independent signalingpathway. [BMB reports 2012; 45(2): 85-90] |
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| ISSN: | 1976-6696 1976-670X |