Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France
Infections with hepatitis E virus (HEV) in solid-organ transplant recipients can lead to chronic hepatitis. However, the incidence of de novo HEV infections after transplantation and risk for reactivation in patients with antibodies against HEV before transplantation are unknown. Pretransplant preva...
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Format: | Article |
Language: | English |
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Centers for Disease Control and Prevention
2011-01-01
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Series: | Emerging Infectious Diseases |
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Online Access: | https://wwwnc.cdc.gov/eid/article/17/1/10-0527_article |
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author | Florence Legrand-Abravanel Nassim Kamar Karine Sandres-Saune Sebastien Lhomme Jean-Michel Mansuy Fabrice Muscari Federico Sallusto Lionel Rostaing Jacques Izopet |
author_facet | Florence Legrand-Abravanel Nassim Kamar Karine Sandres-Saune Sebastien Lhomme Jean-Michel Mansuy Fabrice Muscari Federico Sallusto Lionel Rostaing Jacques Izopet |
author_sort | Florence Legrand-Abravanel |
collection | DOAJ |
description | Infections with hepatitis E virus (HEV) in solid-organ transplant recipients can lead to chronic hepatitis. However, the incidence of de novo HEV infections after transplantation and risk for reactivation in patients with antibodies against HEV before transplantation are unknown. Pretransplant prevalence of these antibodies in 700 solid-organ transplant recipients at Toulouse University Hospital in France was 14.1%. We found no HEV reactivation among patients with antibodies against HEV at the first annual checkup or by measuring liver enzyme activities and HEV RNA. In contrast, we found 34 locally acquired HEV infections among patients with no antibodies against HEV, 47% of whom had a chronic infection, resulting in an incidence of 3.2/100 person-years. Independent risk factors for HEV infection were an age <52 years at transplantation and receiving a liver transplant. Effective prophylactic measures that include those for potential zoonotic infections should reduce the risk for HEV transmission in this population. |
first_indexed | 2024-04-12T06:47:32Z |
format | Article |
id | doaj.art-ee593bee04384603a00aabda594ce8c4 |
institution | Directory Open Access Journal |
issn | 1080-6040 1080-6059 |
language | English |
last_indexed | 2024-04-12T06:47:32Z |
publishDate | 2011-01-01 |
publisher | Centers for Disease Control and Prevention |
record_format | Article |
series | Emerging Infectious Diseases |
spelling | doaj.art-ee593bee04384603a00aabda594ce8c42022-12-22T03:43:31ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592011-01-01171303710.3201/eid1701.100527Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, FranceFlorence Legrand-AbravanelNassim KamarKarine Sandres-SauneSebastien LhommeJean-Michel MansuyFabrice MuscariFederico SallustoLionel RostaingJacques IzopetInfections with hepatitis E virus (HEV) in solid-organ transplant recipients can lead to chronic hepatitis. However, the incidence of de novo HEV infections after transplantation and risk for reactivation in patients with antibodies against HEV before transplantation are unknown. Pretransplant prevalence of these antibodies in 700 solid-organ transplant recipients at Toulouse University Hospital in France was 14.1%. We found no HEV reactivation among patients with antibodies against HEV at the first annual checkup or by measuring liver enzyme activities and HEV RNA. In contrast, we found 34 locally acquired HEV infections among patients with no antibodies against HEV, 47% of whom had a chronic infection, resulting in an incidence of 3.2/100 person-years. Independent risk factors for HEV infection were an age <52 years at transplantation and receiving a liver transplant. Effective prophylactic measures that include those for potential zoonotic infections should reduce the risk for HEV transmission in this population.https://wwwnc.cdc.gov/eid/article/17/1/10-0527_articleHepatitis E virusvirusesincidencereactivationsolid-organ transplant recipientsFrance |
spellingShingle | Florence Legrand-Abravanel Nassim Kamar Karine Sandres-Saune Sebastien Lhomme Jean-Michel Mansuy Fabrice Muscari Federico Sallusto Lionel Rostaing Jacques Izopet Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France Emerging Infectious Diseases Hepatitis E virus viruses incidence reactivation solid-organ transplant recipients France |
title | Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France |
title_full | Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France |
title_fullStr | Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France |
title_full_unstemmed | Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France |
title_short | Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France |
title_sort | hepatitis e virus infection without reactivation in solid organ transplant recipients france |
topic | Hepatitis E virus viruses incidence reactivation solid-organ transplant recipients France |
url | https://wwwnc.cdc.gov/eid/article/17/1/10-0527_article |
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