Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients

Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients

Abstract Aim Neurofibromatosis type 1 (NF1) is a multifaceted disease, and frequently comorbid with neurodevelopmental disorders such as autism spectrum disorder (ASD) and learning disorder. Dysfunction of adenylyl cyclase (AC) is one of the candidate pathways in abnormal development of neuronal cel...

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Main Authors: Noriaki Sagata, Shin‐ichi Kano, Masahiro Ohgidani, Shogo Inamine, Yasunari Sakai, Hiroki Kato, Keiji Masuda, Takeshi Nakahara, Makiko Nakahara‐Kido, Shouichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Takahiro A. Kato
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Neuropsychopharmacology Reports
Subjects:
adenylyl cyclase
autism spectrum disorder
cyclic adenosine monophosphate
forskolin
induced pluripotent stem cells
induced‐neuronal cells
Online Access:https://doi.org/10.1002/npr2.12144

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