Prevention of Postprandial Hyperglycemia by Ophthalmic Nanoparticles Based on Protamine Zinc Insulin in the Rabbit

Prevention of Postprandial Hyperglycemia by Ophthalmic Nanoparticles Based on Protamine Zinc Insulin in the Rabbit

Postprandial hyperglycemia, a so-called blood glucose spike, is associated with enhanced risks of diabetes mellitus (DM) and its complications. In this study, we attempted to design nanoparticles (NPs) of protamine zinc insulin (PZI) by the bead mill method, and prepare ophthalmic formulations based...

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Bibliographic Details
Main Authors: Saori Deguchi, Fumihiko Ogata, Takumi Isaka, Hiroko Otake, Yosuke Nakazawa, Naohito Kawasaki, Noriaki Nagai
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
insulin
nanoparticle
postprandial hyperglycemia
instillation
polyacrylic acid
Online Access:https://www.mdpi.com/1999-4923/13/3/375

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