Immunopathology of chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a litera...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2017-10-01
|
| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/263 |
| _version_ | 1797708708356030464 |
|---|---|
| author | Nora Ernestina Martínez-Aguilar María Eugenia Vargas-Camaño Rogelio Ramsés Hernández-Pliego Genny Margarita Chaia-Semerena María del Rosario Pérez-Chavira |
| author_facet | Nora Ernestina Martínez-Aguilar María Eugenia Vargas-Camaño Rogelio Ramsés Hernández-Pliego Genny Margarita Chaia-Semerena María del Rosario Pérez-Chavira |
| author_sort | Nora Ernestina Martínez-Aguilar |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a literature search for the most relevant documents indexed in the PubMed database over the last 10 years. Different conclusions could be drawn: in COPD immunopathology there are immune and non-immune inflammatory changes with oxidative stress imbalance, there are alterations in the protease/anti-protease ratio caused by direct and indirect genetic and epigenetic-environmental defects; COPD produces irreversible tissue damage and chronic inflammation with tissue repair alteration, which induces chronic obstruction of the airway, bronchitis and systemic damage. Most common resulting comorbidities include cardiovascular disease, metabolic syndrome, osteoporosis, depression, musculoskeletal dysfunction, increased biological age, lung cancer and other types of malignancies. In the conception of COPD, recognizing that it is a non-transmittable and preventable disease is indispensable. |
| first_indexed | 2024-03-12T06:25:27Z |
| format | Article |
| id | doaj.art-ee5c0c3432bd49028b08a11a6f140732 |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T06:25:27Z |
| publishDate | 2017-10-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-ee5c0c3432bd49028b08a11a6f1407322023-09-03T01:57:24ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902017-10-0164332734610.29262/ram.v64i3.263194Immunopathology of chronic obstructive pulmonary diseaseNora Ernestina Martínez-Aguilar0María Eugenia Vargas-Camaño1Rogelio Ramsés Hernández-Pliego2Genny Margarita Chaia-Semerena3María del Rosario Pérez-Chavira4Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio Inmunología Clínica y Alergia, Ciudad de MéxicoAstra-Zeneca, Neumología, Investigación Clínica, Ciudad de MéxicoAstra-Zeneca, Inmunología Clínica y Alergia. Ciudad de MéxicoPráctica privada, Ciudad de MéxicoChronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a literature search for the most relevant documents indexed in the PubMed database over the last 10 years. Different conclusions could be drawn: in COPD immunopathology there are immune and non-immune inflammatory changes with oxidative stress imbalance, there are alterations in the protease/anti-protease ratio caused by direct and indirect genetic and epigenetic-environmental defects; COPD produces irreversible tissue damage and chronic inflammation with tissue repair alteration, which induces chronic obstruction of the airway, bronchitis and systemic damage. Most common resulting comorbidities include cardiovascular disease, metabolic syndrome, osteoporosis, depression, musculoskeletal dysfunction, increased biological age, lung cancer and other types of malignancies. In the conception of COPD, recognizing that it is a non-transmittable and preventable disease is indispensable.http://revistaalergia.mx/ojs/index.php/ram/article/view/263Enfermedad pulmonar obstructiva crónicaInflamación |
| spellingShingle | Nora Ernestina Martínez-Aguilar María Eugenia Vargas-Camaño Rogelio Ramsés Hernández-Pliego Genny Margarita Chaia-Semerena María del Rosario Pérez-Chavira Immunopathology of chronic obstructive pulmonary disease Revista Alergia México Enfermedad pulmonar obstructiva crónica Inflamación |
| title | Immunopathology of chronic obstructive pulmonary disease |
| title_full | Immunopathology of chronic obstructive pulmonary disease |
| title_fullStr | Immunopathology of chronic obstructive pulmonary disease |
| title_full_unstemmed | Immunopathology of chronic obstructive pulmonary disease |
| title_short | Immunopathology of chronic obstructive pulmonary disease |
| title_sort | immunopathology of chronic obstructive pulmonary disease |
| topic | Enfermedad pulmonar obstructiva crónica Inflamación |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/263 |
| work_keys_str_mv | AT noraernestinamartinezaguilar immunopathologyofchronicobstructivepulmonarydisease AT mariaeugeniavargascamano immunopathologyofchronicobstructivepulmonarydisease AT rogelioramseshernandezpliego immunopathologyofchronicobstructivepulmonarydisease AT gennymargaritachaiasemerena immunopathologyofchronicobstructivepulmonarydisease AT mariadelrosarioperezchavira immunopathologyofchronicobstructivepulmonarydisease |