To screen or nor to screen: the prostate cancer dilemma
The European Randomized Study of Screening for Prostate (ERSPC) has updated their previous seminal report on prostate cancer mortality comparing screened men to controls. Now with 13 years follow-up, the rate ratio of prostate cancer mortality was 0.79 favoring the screened population. The authors c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-02-01
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| Series: | Asian Journal of Andrology |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=1;spage=44;epage=45;aulast=Stone |
| _version_ | 1811225340848111616 |
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| author | Nelson N Stone E David Crawford |
| author_facet | Nelson N Stone E David Crawford |
| author_sort | Nelson N Stone |
| collection | DOAJ |
| description | The European Randomized Study of Screening for Prostate (ERSPC) has updated their previous seminal report on prostate cancer mortality comparing screened men to controls. Now with 13 years follow-up, the rate ratio of prostate cancer mortality was 0.79 favoring the screened population. The authors concluded that there was a "substantial reduction in prostate cancer mortality attributable to testing with prostate-specific antigen (PSA)" but they also stated that a "quantification of harms" needed to be addressed. The issue of harms was not addressed by the ERSPC (at least not in this report) and hence this additional statement most likely reflects the controversy currently surrounding the risks associated with over-diagnosis and treatment of indolent diseases inadvertently detected by a screening protocol. [1] In addition, the positive results from this trial conflict with those of the prostate, lung, colorectal and ovarian (PLCO) [2] study and require further elaboration. |
| first_indexed | 2024-04-12T09:05:26Z |
| format | Article |
| id | doaj.art-ee5c8cfb2e7a4d699d141929550aa293 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-04-12T09:05:26Z |
| publishDate | 2015-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-ee5c8cfb2e7a4d699d141929550aa2932022-12-22T03:39:07ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622015-02-01171444510.4103/1008-682X.142770To screen or nor to screen: the prostate cancer dilemma Nelson N StoneE David CrawfordThe European Randomized Study of Screening for Prostate (ERSPC) has updated their previous seminal report on prostate cancer mortality comparing screened men to controls. Now with 13 years follow-up, the rate ratio of prostate cancer mortality was 0.79 favoring the screened population. The authors concluded that there was a "substantial reduction in prostate cancer mortality attributable to testing with prostate-specific antigen (PSA)" but they also stated that a "quantification of harms" needed to be addressed. The issue of harms was not addressed by the ERSPC (at least not in this report) and hence this additional statement most likely reflects the controversy currently surrounding the risks associated with over-diagnosis and treatment of indolent diseases inadvertently detected by a screening protocol. [1] In addition, the positive results from this trial conflict with those of the prostate, lung, colorectal and ovarian (PLCO) [2] study and require further elaboration.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=1;spage=44;epage=45;aulast=Stone |
| spellingShingle | Nelson N Stone E David Crawford To screen or nor to screen: the prostate cancer dilemma Asian Journal of Andrology |
| title | To screen or nor to screen: the prostate cancer dilemma |
| title_full | To screen or nor to screen: the prostate cancer dilemma |
| title_fullStr | To screen or nor to screen: the prostate cancer dilemma |
| title_full_unstemmed | To screen or nor to screen: the prostate cancer dilemma |
| title_short | To screen or nor to screen: the prostate cancer dilemma |
| title_sort | to screen or nor to screen the prostate cancer dilemma |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=1;spage=44;epage=45;aulast=Stone |
| work_keys_str_mv | AT nelsonnstone toscreenornortoscreentheprostatecancerdilemma AT edavidcrawford toscreenornortoscreentheprostatecancerdilemma |