SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis
The characteristics, dynamics and mechanisms/determinants of the immune response to SARS-CoV-2 infection are not fully understood. We performed a bibliometric review of studies that have assessed SARS-CoV-2 antibody responses in the pediatric population using Web of Science online databases, VOSview...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/5/1455 |
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| author | Ionela Maniu George Constantin Maniu Elisabeta Antonescu Lavinia Duica Nicolae Grigore Maria Totan |
| author_facet | Ionela Maniu George Constantin Maniu Elisabeta Antonescu Lavinia Duica Nicolae Grigore Maria Totan |
| author_sort | Ionela Maniu |
| collection | DOAJ |
| description | The characteristics, dynamics and mechanisms/determinants of the immune response to SARS-CoV-2 infection are not fully understood. We performed a bibliometric review of studies that have assessed SARS-CoV-2 antibody responses in the pediatric population using Web of Science online databases, VOSviewer and Bibliometrix tools. The analysis was conducted on 84 publications, from 310 institutions located in 29 countries and published in 57 journals. The results showed the collaboration of scientists and organizations, international research interactions and summarized the findings on (i) the measured titers of antibodies (total antibody and/or individual antibody classes IgG, IgM, IgA) against different antigens (C-terminal region of N (N CT), full-length N protein (N FL), RBD, RBD Alpha, RBD Beta, RBD Gamma, RBD Delta, spike (S), S1, S2) in the case of different clinical forms of the disease; and (ii) the correlations between SARS-CoV-2 antibodies and cytokines, chemokines, neutrophils, C-reactive protein, ferritin, and the erythrocyte sedimentation rate. The presented study offers insights regarding research directions to be explored in the studied field and may provide a starting point for future research. |
| first_indexed | 2024-03-11T03:55:16Z |
| format | Article |
| id | doaj.art-ee5e7439834a48649a5c8188417a53a7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:55:16Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ee5e7439834a48649a5c8188417a53a72023-11-18T00:37:22ZengMDPI AGBiomedicines2227-90592023-05-01115145510.3390/biomedicines11051455SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric AnalysisIonela Maniu0George Constantin Maniu1Elisabeta Antonescu2Lavinia Duica3Nicolae Grigore4Maria Totan5Mathematics and Informatics Department, Research Center in Informatics and Information Technology, Faculty of Sciences, “Lucian Blaga” University, 5-7 Ion Ratiu Str., 550025 Sibiu, RomaniaMathematics and Informatics Department, Research Center in Informatics and Information Technology, Faculty of Sciences, “Lucian Blaga” University, 5-7 Ion Ratiu Str., 550025 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaThe characteristics, dynamics and mechanisms/determinants of the immune response to SARS-CoV-2 infection are not fully understood. We performed a bibliometric review of studies that have assessed SARS-CoV-2 antibody responses in the pediatric population using Web of Science online databases, VOSviewer and Bibliometrix tools. The analysis was conducted on 84 publications, from 310 institutions located in 29 countries and published in 57 journals. The results showed the collaboration of scientists and organizations, international research interactions and summarized the findings on (i) the measured titers of antibodies (total antibody and/or individual antibody classes IgG, IgM, IgA) against different antigens (C-terminal region of N (N CT), full-length N protein (N FL), RBD, RBD Alpha, RBD Beta, RBD Gamma, RBD Delta, spike (S), S1, S2) in the case of different clinical forms of the disease; and (ii) the correlations between SARS-CoV-2 antibodies and cytokines, chemokines, neutrophils, C-reactive protein, ferritin, and the erythrocyte sedimentation rate. The presented study offers insights regarding research directions to be explored in the studied field and may provide a starting point for future research.https://www.mdpi.com/2227-9059/11/5/1455antibodiesCOVID-19bibliometric analysisdisease severityinflammatory markersVOSviewer |
| spellingShingle | Ionela Maniu George Constantin Maniu Elisabeta Antonescu Lavinia Duica Nicolae Grigore Maria Totan SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis Biomedicines antibodies COVID-19 bibliometric analysis disease severity inflammatory markers VOSviewer |
| title | SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis |
| title_full | SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis |
| title_fullStr | SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis |
| title_full_unstemmed | SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis |
| title_short | SARS-CoV-2 Antibody Responses in Pediatric Patients: A Bibliometric Analysis |
| title_sort | sars cov 2 antibody responses in pediatric patients a bibliometric analysis |
| topic | antibodies COVID-19 bibliometric analysis disease severity inflammatory markers VOSviewer |
| url | https://www.mdpi.com/2227-9059/11/5/1455 |
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