Transcription factor E3 renal cell carcinoma presenting as secondary hypertension
Abstract. Microphthalmia-associated transcription factor family (transcription factor E3 or transcription factor EB) translocation renal cell carcinomas (RCCs) are rare neoplasms. These renal neoplasms can be either asymptomatic and incidentally discovered on imaging or symptomatic, with the most co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2023-03-01
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| Series: | Current Urology |
| Online Access: | http://journals.lww.com/10.1097/CU9.0000000000000108 |
| _version_ | 1797690679746363392 |
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| author | Alain Mwamba Mukendi Gerald Tatenda Mataruka Ramesh Nadimpalli Tshisola Miji Kasapato |
| author_facet | Alain Mwamba Mukendi Gerald Tatenda Mataruka Ramesh Nadimpalli Tshisola Miji Kasapato |
| author_sort | Alain Mwamba Mukendi |
| collection | DOAJ |
| description | Abstract. Microphthalmia-associated transcription factor family (transcription factor E3 or transcription factor EB) translocation renal cell carcinomas (RCCs) are rare neoplasms. These renal neoplasms can be either asymptomatic and incidentally discovered on imaging or symptomatic, with the most common presenting symptoms being hematuria, pain, and abdominal mass, or paraneoplastic event. In conventional RCCs, hypertension is considered a risk factor and a possible paraneoplastic event, whereas, in translocation RCCs, prior exposure to cytotoxic chemotherapy is the only known risk factor, and hypertension as an isolated associated paraneoplastic event has never been reported. Interestingly, hypertension as the only presenting symptom in RCC is extremely rare. We report a case of transcription factor E3 positive RCC in a young adult presenting only with hypertension that normalized after radical nephrectomy. To the best of our knowledge, this is the first reported case of hypertension secondary to microphthalmia-associated transcription translocation RCC. |
| first_indexed | 2024-03-12T02:03:43Z |
| format | Article |
| id | doaj.art-ee5ef32b5ef24caba5371d9e3ae22d38 |
| institution | Directory Open Access Journal |
| issn | 1661-7649 |
| language | English |
| last_indexed | 2024-03-12T02:03:43Z |
| publishDate | 2023-03-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Current Urology |
| spelling | doaj.art-ee5ef32b5ef24caba5371d9e3ae22d382023-09-07T09:31:01ZengWolters Kluwer HealthCurrent Urology1661-76492023-03-01171586110.1097/CU9.0000000000000108202303000-00011Transcription factor E3 renal cell carcinoma presenting as secondary hypertensionAlain Mwamba Mukendi0Gerald Tatenda Mataruka1Ramesh Nadimpalli2Tshisola Miji Kasapato3Thelle Mogoerane Regional Hospital, Division of Urology, Department of Surgery, University of the Witwatersrand, Johannesburg, South AfricaThelle Mogoerane Regional Hospital, Division of Urology, Department of Surgery, University of the Witwatersrand, Johannesburg, South AfricaThelle Mogoerane Regional Hospital, Division of Urology, Department of Surgery, University of the Witwatersrand, Johannesburg, South AfricaThelle Mogoerane Regional Hospital, Division of Urology, Department of Surgery, University of the Witwatersrand, Johannesburg, South AfricaAbstract. Microphthalmia-associated transcription factor family (transcription factor E3 or transcription factor EB) translocation renal cell carcinomas (RCCs) are rare neoplasms. These renal neoplasms can be either asymptomatic and incidentally discovered on imaging or symptomatic, with the most common presenting symptoms being hematuria, pain, and abdominal mass, or paraneoplastic event. In conventional RCCs, hypertension is considered a risk factor and a possible paraneoplastic event, whereas, in translocation RCCs, prior exposure to cytotoxic chemotherapy is the only known risk factor, and hypertension as an isolated associated paraneoplastic event has never been reported. Interestingly, hypertension as the only presenting symptom in RCC is extremely rare. We report a case of transcription factor E3 positive RCC in a young adult presenting only with hypertension that normalized after radical nephrectomy. To the best of our knowledge, this is the first reported case of hypertension secondary to microphthalmia-associated transcription translocation RCC.http://journals.lww.com/10.1097/CU9.0000000000000108 |
| spellingShingle | Alain Mwamba Mukendi Gerald Tatenda Mataruka Ramesh Nadimpalli Tshisola Miji Kasapato Transcription factor E3 renal cell carcinoma presenting as secondary hypertension Current Urology |
| title | Transcription factor E3 renal cell carcinoma presenting as secondary hypertension |
| title_full | Transcription factor E3 renal cell carcinoma presenting as secondary hypertension |
| title_fullStr | Transcription factor E3 renal cell carcinoma presenting as secondary hypertension |
| title_full_unstemmed | Transcription factor E3 renal cell carcinoma presenting as secondary hypertension |
| title_short | Transcription factor E3 renal cell carcinoma presenting as secondary hypertension |
| title_sort | transcription factor e3 renal cell carcinoma presenting as secondary hypertension |
| url | http://journals.lww.com/10.1097/CU9.0000000000000108 |
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