uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS
Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Goiás
2013-06-01
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| Series: | Ciência Animal Brasileira |
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| Online Access: | https://revistas.ufg.br/vet/article/view/18930 |
| _version_ | 1797790160707911680 |
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| author | Mariana Rodrigues Faleiro Denise Caroline Toledo Marcela M. Pinto Rodrigues Renee Laufer Amorim Luiz Augusto B. Brito Adilson Donizeti Damasceno Veridiana M. B. Dignani de Moura |
| author_facet | Mariana Rodrigues Faleiro Denise Caroline Toledo Marcela M. Pinto Rodrigues Renee Laufer Amorim Luiz Augusto B. Brito Adilson Donizeti Damasceno Veridiana M. B. Dignani de Moura |
| author_sort | Mariana Rodrigues Faleiro |
| collection | DOAJ |
| description |
Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.
KEYWORDS: CD87; PIA; PIN; prostatic carcinoma; TMA.
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| first_indexed | 2024-03-13T02:00:48Z |
| format | Article |
| id | doaj.art-ee60d3d19c2e412ba1b6ceb13685d5f2 |
| institution | Directory Open Access Journal |
| issn | 1518-2797 1809-6891 |
| language | English |
| last_indexed | 2024-03-13T02:00:48Z |
| publishDate | 2013-06-01 |
| publisher | Universidade Federal de Goiás |
| record_format | Article |
| series | Ciência Animal Brasileira |
| spelling | doaj.art-ee60d3d19c2e412ba1b6ceb13685d5f22023-07-01T21:05:48ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912013-06-01142uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERSMariana Rodrigues Faleiro0Denise Caroline Toledo1Marcela M. Pinto Rodrigues2Renee Laufer Amorim3Luiz Augusto B. Brito4Adilson Donizeti Damasceno5Veridiana M. B. Dignani de Moura6UFG- Universidade Federal de GoiásUniversidade Federal de GoiásUniversidade estadual Paulista Julio de Mesquita Filho campus-Botucatu-spUniversidade estadual Paulista Julio de Mesquita Filho campus-Botucatu-spUniversidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de Goiás Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC. KEYWORDS: CD87; PIA; PIN; prostatic carcinoma; TMA. https://revistas.ufg.br/vet/article/view/18930Animal Sanity |
| spellingShingle | Mariana Rodrigues Faleiro Denise Caroline Toledo Marcela M. Pinto Rodrigues Renee Laufer Amorim Luiz Augusto B. Brito Adilson Donizeti Damasceno Veridiana M. B. Dignani de Moura uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS Ciência Animal Brasileira Animal Sanity |
| title | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_full | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_fullStr | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_full_unstemmed | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_short | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_sort | upar expression in canine normal prostate and with proliferative disorders |
| topic | Animal Sanity |
| url | https://revistas.ufg.br/vet/article/view/18930 |
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