Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery.
INTRODUCTION:Cardiac surgery with the use of cardiopulmonary bypass is known to induce distinct metabolic changes. Respective changes in acid-base status including increased systemic lactate levels were previously related to clinical outcomes, but data remain controversial. Therefore, we aim to inve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6173442?pdf=render |
| _version_ | 1811293300183793664 |
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| author | Bjoern Zante Hermann Reichenspurner Mathias Kubik Stefan Kluge Joerg C Schefold Carmen A Pfortmueller |
| author_facet | Bjoern Zante Hermann Reichenspurner Mathias Kubik Stefan Kluge Joerg C Schefold Carmen A Pfortmueller |
| author_sort | Bjoern Zante |
| collection | DOAJ |
| description | INTRODUCTION:Cardiac surgery with the use of cardiopulmonary bypass is known to induce distinct metabolic changes. Respective changes in acid-base status including increased systemic lactate levels were previously related to clinical outcomes, but data remain controversial. Therefore, we aim to investigate the relevance of lactate and base excess (BE) levels on ICU-mortality in patients admitted to the ICU after cardiac surgery. MATERIALS AND METHODS:Perioperative data of patients treated in a tertiary care academic center admitted to the ICU after on-pump surgery were analyzed in a retrospective fashion. Receiver operation characteristic (ROC) curves were constructed for admission lactate-levels and BE with calculation of optimal cut-off values to predict ICU mortality. Univariate followed by multivariate regression models were constructed to identify potential outcome-relevant indices. RESULTS:Data from 1,058 patients were included in the analysis. Area under the curves for prediction of ICU mortality were 0.79 for lactate levels at ICU admission (sensitivity 61.9%/ specificity 87.5%; optimal cut-off level 3.9mmol/l), and 0.7 for BE (sensitivity 52.4%/ specificity 93.8%, optimal cut-off level -6.7), respectively. Multivariate regression identified BE < -6.7 as the single metabolic predictor of ICU-mortality (HR 4.78, 95%-CI 1.4-16.33, p = 0.01). Explorative subgroup analyses revealed that the combination of lactate ≤3.9mmol/l and BE ≤ -6.7 has stronger impact on mortality than a combination of lactate of >3.9mmol/l and BE > -6.7 (HR 2.56, 95%-CI 0.18-37.17). CONCLUSIONS:At ICU-admission, severely reduced BE appears superior to hyperlactatemia with regard to prediction of ICU-mortality in patients after cardiac surgery. |
| first_indexed | 2024-04-13T04:59:23Z |
| format | Article |
| id | doaj.art-ee629989b9aa4ab397e6409916e20812 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T04:59:23Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ee629989b9aa4ab397e6409916e208122022-12-22T03:01:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020530910.1371/journal.pone.0205309Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery.Bjoern ZanteHermann ReichenspurnerMathias KubikStefan KlugeJoerg C SchefoldCarmen A PfortmuellerINTRODUCTION:Cardiac surgery with the use of cardiopulmonary bypass is known to induce distinct metabolic changes. Respective changes in acid-base status including increased systemic lactate levels were previously related to clinical outcomes, but data remain controversial. Therefore, we aim to investigate the relevance of lactate and base excess (BE) levels on ICU-mortality in patients admitted to the ICU after cardiac surgery. MATERIALS AND METHODS:Perioperative data of patients treated in a tertiary care academic center admitted to the ICU after on-pump surgery were analyzed in a retrospective fashion. Receiver operation characteristic (ROC) curves were constructed for admission lactate-levels and BE with calculation of optimal cut-off values to predict ICU mortality. Univariate followed by multivariate regression models were constructed to identify potential outcome-relevant indices. RESULTS:Data from 1,058 patients were included in the analysis. Area under the curves for prediction of ICU mortality were 0.79 for lactate levels at ICU admission (sensitivity 61.9%/ specificity 87.5%; optimal cut-off level 3.9mmol/l), and 0.7 for BE (sensitivity 52.4%/ specificity 93.8%, optimal cut-off level -6.7), respectively. Multivariate regression identified BE < -6.7 as the single metabolic predictor of ICU-mortality (HR 4.78, 95%-CI 1.4-16.33, p = 0.01). Explorative subgroup analyses revealed that the combination of lactate ≤3.9mmol/l and BE ≤ -6.7 has stronger impact on mortality than a combination of lactate of >3.9mmol/l and BE > -6.7 (HR 2.56, 95%-CI 0.18-37.17). CONCLUSIONS:At ICU-admission, severely reduced BE appears superior to hyperlactatemia with regard to prediction of ICU-mortality in patients after cardiac surgery.http://europepmc.org/articles/PMC6173442?pdf=render |
| spellingShingle | Bjoern Zante Hermann Reichenspurner Mathias Kubik Stefan Kluge Joerg C Schefold Carmen A Pfortmueller Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. PLoS ONE |
| title | Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. |
| title_full | Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. |
| title_fullStr | Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. |
| title_full_unstemmed | Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. |
| title_short | Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. |
| title_sort | base excess is superior to lactate levels in prediction of icu mortality after cardiac surgery |
| url | http://europepmc.org/articles/PMC6173442?pdf=render |
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