Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the major causes of dementia and its incidence represents approximately 60–70% of all dementia cases worldwide. Many theories have been proposed to describe the pathological events in AD, including deterioration in cognitive function, accumulation of β-amyloid, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Neuroglia |
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| Online Access: | https://www.mdpi.com/2571-6980/4/3/14 |
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| author | Ahmed M. Elshazly Melanie M. Sinanian Diaaeldin M. Elimam Sherin Zakaria |
| author_facet | Ahmed M. Elshazly Melanie M. Sinanian Diaaeldin M. Elimam Sherin Zakaria |
| author_sort | Ahmed M. Elshazly |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is one of the major causes of dementia and its incidence represents approximately 60–70% of all dementia cases worldwide. Many theories have been proposed to describe the pathological events in AD, including deterioration in cognitive function, accumulation of β-amyloid, and tau protein hyperphosphorylation. Infection as well as various cellular molecules, such as apolipoprotein, micro-RNA, calcium, ghrelin receptor, and probiotics, are associated with the disruption of β-amyloid and tau protein hemostasis. This review gives an overview on the integrative cellular and signaling molecules that could play a complementary role in the dysregulation of β-amyloid and tau proteins. |
| first_indexed | 2024-03-10T22:21:46Z |
| format | Article |
| id | doaj.art-ee639215614f485c94078b1d58e047d2 |
| institution | Directory Open Access Journal |
| issn | 2571-6980 |
| language | English |
| last_indexed | 2024-03-10T22:21:46Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neuroglia |
| spelling | doaj.art-ee639215614f485c94078b1d58e047d22023-11-19T12:15:38ZengMDPI AGNeuroglia2571-69802023-07-014319120810.3390/neuroglia4030014Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s DiseaseAhmed M. Elshazly0Melanie M. Sinanian1Diaaeldin M. Elimam2Sherin Zakaria3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, EgyptDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, EgyptAlzheimer’s disease (AD) is one of the major causes of dementia and its incidence represents approximately 60–70% of all dementia cases worldwide. Many theories have been proposed to describe the pathological events in AD, including deterioration in cognitive function, accumulation of β-amyloid, and tau protein hyperphosphorylation. Infection as well as various cellular molecules, such as apolipoprotein, micro-RNA, calcium, ghrelin receptor, and probiotics, are associated with the disruption of β-amyloid and tau protein hemostasis. This review gives an overview on the integrative cellular and signaling molecules that could play a complementary role in the dysregulation of β-amyloid and tau proteins.https://www.mdpi.com/2571-6980/4/3/14Alzheimer’sβ-amyloidtau proteincalciumprobioticsapolipoprotein |
| spellingShingle | Ahmed M. Elshazly Melanie M. Sinanian Diaaeldin M. Elimam Sherin Zakaria Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease Neuroglia Alzheimer’s β-amyloid tau protein calcium probiotics apolipoprotein |
| title | Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease |
| title_full | Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease |
| title_fullStr | Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease |
| title_full_unstemmed | Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease |
| title_short | Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease |
| title_sort | overview of the molecular modalities and signaling pathways intersecting with β amyloid and tau protein in alzheimer s disease |
| topic | Alzheimer’s β-amyloid tau protein calcium probiotics apolipoprotein |
| url | https://www.mdpi.com/2571-6980/4/3/14 |
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