The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension
Background. The article presents data on the state of cytokine regulation, indicators of endothelial damage when exposed to industrial vibration (general, local) and in combination with arterial hypertension. Aim. To improve the quality of early diagnosis and prevention of vibration disease in an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2021-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/75961/56551 |
| _version_ | 1819096033399930880 |
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| author | Sergei A. Babanov Rimma A. Baraeva Leonid A. Strizhakov Sergei V. Moiseev Viktor V. Fomin |
| author_facet | Sergei A. Babanov Rimma A. Baraeva Leonid A. Strizhakov Sergei V. Moiseev Viktor V. Fomin |
| author_sort | Sergei A. Babanov |
| collection | DOAJ |
| description | Background. The article presents data on the state of cytokine regulation, indicators of endothelial damage when exposed to industrial vibration (general, local) and in combination with arterial hypertension.
Aim. To improve the quality of early diagnosis and prevention of vibration disease in an isolated course and its combination with arterial hypertension based on a study of the cytokine profile, biomarkers of endothelial dysfunction in this pathology.
Materials and methods. A comprehensive survey of 84 patients with isolated vibration disease from the effects of local, general, first, second degree and 61 patients with a combined course of vibration disease from the effects of local, general second degree vibration and arterial hypertension, 30 people in the control group without contact with industrial vibration and found healthy by medical examination. The levels of pro-inflammatory (IL-1, IL-8, TNF-) and anti-inflammatory cytokines (IL-4), biomarkers of endothelial damage (EDN-1, TGF-1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor) were determined using the enzyme immunoassay method.
Results. The response of the immune system to the effects of industrial vibration is characterized by a cytokine imbalance an increase in the level of pro-inflammatory cytokines (IL-1, IL-8, TNF-) and a decrease in the level of anti-inflammatory cytokine (IL-4). With a combined course of vibratory disease and arterial hypertension, the cytokine imbalance is characterized by an even more significant increase in serum IL-1, IL-8, TNF- and a decrease in serum IL-4 concentration. Endothelial dysfunction with WB from the action of both local and general vibration in combination with hypertension is characterized by a significant increase in serum EDN-1, TGF-1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor.
Conclusion. The study of the cytokine profile, biomarkers of damage to the vascular endothelium in this pathology will allow for the early diagnosis of vascular disorders and to optimize preventive measures for workers in vibration-hazardous industries. |
| first_indexed | 2024-12-21T23:52:46Z |
| format | Article |
| id | doaj.art-ee63d147fd6448d9af388c8802a8eaca |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T23:52:46Z |
| publishDate | 2021-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-ee63d147fd6448d9af388c8802a8eaca2022-12-21T18:45:53Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422021-06-0193669369810.26442/00403660.2021.06.20088069634The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertensionSergei A. Babanov0https://orcid.org/0000-0002-1667-737XRimma A. Baraeva1https://orcid.org/0000-0002-4502-4140Leonid A. Strizhakov2https://orcid.org/0000-0002-2291-6453Sergei V. Moiseev3https://orcid.org/0000-0002-7232-4640Viktor V. Fomin4https://orcid.org/0000-0002-2682-4417Samara State Medical UniversitySamara Medical and Sanitary Unit №5 of the Kirovsky DistrictSechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Background. The article presents data on the state of cytokine regulation, indicators of endothelial damage when exposed to industrial vibration (general, local) and in combination with arterial hypertension. Aim. To improve the quality of early diagnosis and prevention of vibration disease in an isolated course and its combination with arterial hypertension based on a study of the cytokine profile, biomarkers of endothelial dysfunction in this pathology. Materials and methods. A comprehensive survey of 84 patients with isolated vibration disease from the effects of local, general, first, second degree and 61 patients with a combined course of vibration disease from the effects of local, general second degree vibration and arterial hypertension, 30 people in the control group without contact with industrial vibration and found healthy by medical examination. The levels of pro-inflammatory (IL-1, IL-8, TNF-) and anti-inflammatory cytokines (IL-4), biomarkers of endothelial damage (EDN-1, TGF-1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor) were determined using the enzyme immunoassay method. Results. The response of the immune system to the effects of industrial vibration is characterized by a cytokine imbalance an increase in the level of pro-inflammatory cytokines (IL-1, IL-8, TNF-) and a decrease in the level of anti-inflammatory cytokine (IL-4). With a combined course of vibratory disease and arterial hypertension, the cytokine imbalance is characterized by an even more significant increase in serum IL-1, IL-8, TNF- and a decrease in serum IL-4 concentration. Endothelial dysfunction with WB from the action of both local and general vibration in combination with hypertension is characterized by a significant increase in serum EDN-1, TGF-1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor. Conclusion. The study of the cytokine profile, biomarkers of damage to the vascular endothelium in this pathology will allow for the early diagnosis of vascular disorders and to optimize preventive measures for workers in vibration-hazardous industries.https://ter-arkhiv.ru/0040-3660/article/viewFile/75961/56551vibration diseasearterial hypertensioncytokine profileendothelial dysfunction |
| spellingShingle | Sergei A. Babanov Rimma A. Baraeva Leonid A. Strizhakov Sergei V. Moiseev Viktor V. Fomin The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension Терапевтический архив vibration disease arterial hypertension cytokine profile endothelial dysfunction |
| title | The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension |
| title_full | The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension |
| title_fullStr | The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension |
| title_full_unstemmed | The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension |
| title_short | The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension |
| title_sort | state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension |
| topic | vibration disease arterial hypertension cytokine profile endothelial dysfunction |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/75961/56551 |
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