The Development, Fine Specificity, and Importance of High-Avidity Antibodies to VAR2CSA in Pregnant Cameroonian Women Living in Yaoundé, an Urban City

The Development, Fine Specificity, and Importance of High-Avidity Antibodies to VAR2CSA in Pregnant Cameroonian Women Living in Yaoundé, an Urban City

Pregnant women infected with Plasmodium falciparum often produce antibodies (Abs) to VAR2CSA, a ligand that binds to placental chondroitin sulfate A causing placental malaria (PM). Antibodies to VAR2CSA are associated with improved pregnancy outcomes. Antibody avidity is a surrogate marker for the e...

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Bibliographic Details
Main Authors: Koko Vanda, Naveen Bobbili, Masako Matsunaga, John J. Chen, Ali Salanti, Rose F. G. Leke, Diane Wallace Taylor
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Plasmodium falciparum
pregnant women
placental malaria
VAR2CSA
antibody avidity
urban cities
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.610108/full

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