Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Abstract Background The biguanide metformin has been shown to not only reduce circulating glucose levels but also suppress in vitro and in vivo growth of prostate cancer. However, the mechanisms underlying the anti-tumor effects of metformin in advanced prostate cancers are not fully understood. The...

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Bibliographic Details
Main Authors: Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap, La Monica V. Stewart
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Cancer
Subjects:
Prostate
Androgen receptor
p53
Metformin
Online Access:https://doi.org/10.1186/s12885-022-10115-3

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