Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy
Kalathil K SureshkumarDivision of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, Pennsylvania, USAAbstract: Hypertension is a major risk factor for the development of cardiovascular and renal disease. The incidence of hypertension is increasing globally and the rate of blood pr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2008-12-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/renin-inhibition-with-aliskiren-in-hypertension-focus-on-aliskirenhydr-peer-reviewed-article-VHRM |
| _version_ | 1828852093696344064 |
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| author | Kalathil K Sureshkumar |
| author_facet | Kalathil K Sureshkumar |
| author_sort | Kalathil K Sureshkumar |
| collection | DOAJ |
| description | Kalathil K SureshkumarDivision of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, Pennsylvania, USAAbstract: Hypertension is a major risk factor for the development of cardiovascular and renal disease. The incidence of hypertension is increasing globally and the rate of blood pressure control remains inadequate. Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in volume regulation and maintenance of blood pressure. Pathological activation of RAAS results in chronic hypertension and consequent end organ damage. Most patients with hypertension require combination therapy using agents with complimentary mechanisms of action. Hydrochlorothiazide (HCTZ) together with an agent blocking the RAAS such as an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) are widely used effective anti-hypertensive therapy. Aliskiren is an orally effective direct renin inhibitor that blocks the generation of angiotensin I from angiotensinogen, the rate limiting step of RAAS activation. Studies have shown equivalent antihypertensive efficacy of aliskiren when compared to existing medications such as HCTZ, ACE inhibitors and ARBs. Aliskiren has also been tested in combination therapies. The current review aims to look at the efficacy of aliskiren therapy in hypertension and the evidence for using aliskiren in combination with HCTZ.Keywords: hypertension, renin-angiotensin-aldosterone system, aliskiren, aliskiren-hydrochlorothiazide, combination therapy, renin inhibitors |
| first_indexed | 2024-12-12T23:45:28Z |
| format | Article |
| id | doaj.art-ee65c83fd8cc4a51a77b189966321d2e |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-12T23:45:28Z |
| publishDate | 2008-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-ee65c83fd8cc4a51a77b189966321d2e2022-12-22T00:06:53ZengDove Medical PressVascular Health and Risk Management1178-20482008-12-01Volume 4120512202538Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapyKalathil K SureshkumarKalathil K SureshkumarDivision of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, Pennsylvania, USAAbstract: Hypertension is a major risk factor for the development of cardiovascular and renal disease. The incidence of hypertension is increasing globally and the rate of blood pressure control remains inadequate. Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in volume regulation and maintenance of blood pressure. Pathological activation of RAAS results in chronic hypertension and consequent end organ damage. Most patients with hypertension require combination therapy using agents with complimentary mechanisms of action. Hydrochlorothiazide (HCTZ) together with an agent blocking the RAAS such as an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) are widely used effective anti-hypertensive therapy. Aliskiren is an orally effective direct renin inhibitor that blocks the generation of angiotensin I from angiotensinogen, the rate limiting step of RAAS activation. Studies have shown equivalent antihypertensive efficacy of aliskiren when compared to existing medications such as HCTZ, ACE inhibitors and ARBs. Aliskiren has also been tested in combination therapies. The current review aims to look at the efficacy of aliskiren therapy in hypertension and the evidence for using aliskiren in combination with HCTZ.Keywords: hypertension, renin-angiotensin-aldosterone system, aliskiren, aliskiren-hydrochlorothiazide, combination therapy, renin inhibitorshttps://www.dovepress.com/renin-inhibition-with-aliskiren-in-hypertension-focus-on-aliskirenhydr-peer-reviewed-article-VHRMHypertensionrenin-angiotensin-aldosterone systemaliskiren-hydrochlorothiazidecombination therapyrenin inhibitors |
| spellingShingle | Kalathil K Sureshkumar Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy Vascular Health and Risk Management Hypertension renin-angiotensin-aldosterone system aliskiren-hydrochlorothiazide combination therapy renin inhibitors |
| title | Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy |
| title_full | Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy |
| title_fullStr | Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy |
| title_full_unstemmed | Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy |
| title_short | Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy |
| title_sort | renin inhibition with aliskiren in hypertension focus on aliskiren hydrochlorothiazide combination therapy |
| topic | Hypertension renin-angiotensin-aldosterone system aliskiren-hydrochlorothiazide combination therapy renin inhibitors |
| url | https://www.dovepress.com/renin-inhibition-with-aliskiren-in-hypertension-focus-on-aliskirenhydr-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT kalathilksureshkumar renininhibitionwithaliskireninhypertensionfocusonaliskirenhydrochlorothiazidecombinationtherapy |