Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections
In terms of the global burden of disease, helminthiasis is the most common infectious disease in the world. In response to the disease, the human host develops an immunological response that occurs predominantly through the action of T helper 2 (Th2) cells and the interleukins IL-4, IL-5 and IL-13....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Immuno |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-5601/3/2/15 |
| _version_ | 1827737067273060352 |
|---|---|
| author | Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Tatyane Martins Cirilo Ricardo Toshio Fujiwara Lilian Lacerda Bueno Silvio Santana Dolabella |
| author_facet | Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Tatyane Martins Cirilo Ricardo Toshio Fujiwara Lilian Lacerda Bueno Silvio Santana Dolabella |
| author_sort | Yvanna Louise Di Christine Oliveira |
| collection | DOAJ |
| description | In terms of the global burden of disease, helminthiasis is the most common infectious disease in the world. In response to the disease, the human host develops an immunological response that occurs predominantly through the action of T helper 2 (Th2) cells and the interleukins IL-4, IL-5 and IL-13. However, other types of Th cells, such as Th9, are also involved in the defense against helminths, with the IL-9 produced by these cells promoting the induction of mastocytosis and the increased production of IgG1 and IgE, in addition to the increase in intestinal contractility that promotes the expulsion of worms. Together, IL-9 and IL-10, which is also produced by Th9, induce a type 2 inflammatory response characterized by the coordinated actions of innate lymphoid cells, mast cells, basophils and other cells that work together toward a single objective: the reduction of the parasitic burden. This review presents the latest findings on Th9 effector mechanisms in helminthic infections. |
| first_indexed | 2024-03-11T02:20:52Z |
| format | Article |
| id | doaj.art-ee65eea0aeec40be9f395d5f8a91b611 |
| institution | Directory Open Access Journal |
| issn | 2673-5601 |
| language | English |
| last_indexed | 2024-03-11T02:20:52Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Immuno |
| spelling | doaj.art-ee65eea0aeec40be9f395d5f8a91b6112023-11-18T10:53:53ZengMDPI AGImmuno2673-56012023-06-013222823610.3390/immuno3020015Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth InfectionsYvanna Louise Di Christine Oliveira0Yrna Lorena Matos de Oliveira1Tatyane Martins Cirilo2Ricardo Toshio Fujiwara3Lilian Lacerda Bueno4Silvio Santana Dolabella5Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, SE, BrazilPostgraduate Program in Health Sciences, Federal University of Sergipe, São Cristóvão 49100-000, SE, BrazilDepartment of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilDepartment of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilDepartment of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilPostgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, SE, BrazilIn terms of the global burden of disease, helminthiasis is the most common infectious disease in the world. In response to the disease, the human host develops an immunological response that occurs predominantly through the action of T helper 2 (Th2) cells and the interleukins IL-4, IL-5 and IL-13. However, other types of Th cells, such as Th9, are also involved in the defense against helminths, with the IL-9 produced by these cells promoting the induction of mastocytosis and the increased production of IgG1 and IgE, in addition to the increase in intestinal contractility that promotes the expulsion of worms. Together, IL-9 and IL-10, which is also produced by Th9, induce a type 2 inflammatory response characterized by the coordinated actions of innate lymphoid cells, mast cells, basophils and other cells that work together toward a single objective: the reduction of the parasitic burden. This review presents the latest findings on Th9 effector mechanisms in helminthic infections.https://www.mdpi.com/2673-5601/3/2/15helminthiasisimmune responseT-lymphocyte subsetsinflammation |
| spellingShingle | Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Tatyane Martins Cirilo Ricardo Toshio Fujiwara Lilian Lacerda Bueno Silvio Santana Dolabella Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections Immuno helminthiasis immune response T-lymphocyte subsets inflammation |
| title | Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections |
| title_full | Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections |
| title_fullStr | Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections |
| title_full_unstemmed | Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections |
| title_short | Inflammatory Profile of Th9 Cells and Their Protective Potential in Helminth Infections |
| title_sort | inflammatory profile of th9 cells and their protective potential in helminth infections |
| topic | helminthiasis immune response T-lymphocyte subsets inflammation |
| url | https://www.mdpi.com/2673-5601/3/2/15 |
| work_keys_str_mv | AT yvannalouisedichristineoliveira inflammatoryprofileofth9cellsandtheirprotectivepotentialinhelminthinfections AT yrnalorenamatosdeoliveira inflammatoryprofileofth9cellsandtheirprotectivepotentialinhelminthinfections AT tatyanemartinscirilo inflammatoryprofileofth9cellsandtheirprotectivepotentialinhelminthinfections AT ricardotoshiofujiwara inflammatoryprofileofth9cellsandtheirprotectivepotentialinhelminthinfections AT lilianlacerdabueno inflammatoryprofileofth9cellsandtheirprotectivepotentialinhelminthinfections AT silviosantanadolabella inflammatoryprofileofth9cellsandtheirprotectivepotentialinhelminthinfections |