Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations
Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2021.637682/full |
| _version_ | 1818608199504232448 |
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| author | Navapon Techakriengkrai Navapon Techakriengkrai Navapon Techakriengkrai Teerawut Nedumpun Teerawut Nedumpun William T. Golde Sanipa Suradhat Sanipa Suradhat |
| author_facet | Navapon Techakriengkrai Navapon Techakriengkrai Navapon Techakriengkrai Teerawut Nedumpun Teerawut Nedumpun William T. Golde Sanipa Suradhat Sanipa Suradhat |
| author_sort | Navapon Techakriengkrai |
| collection | DOAJ |
| description | Among swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the commercial pig populations. In this study, a total number of 158 pigs (126 gilts and 32 boars) were randomly selected from different breeding herds of five major pig-producing companies, which covered ~70% of Thai swine production. The results indicate that a moderate level of SLA diversity was maintained in the Thai swine population, despite the performance-oriented breeding scheme. The highly common SLA class I alleles were SLA-1*08:XX, SLA-2*02:XX, and SLA-3*04:XX at a combined frequency of 30.1, 18.4, and 34.5%, respectively, whereas DRB1*04:XX, DQB1*02:XX and DQA*02:XX were the common class II alleles at 22.8, 33.3, and 38.6%, respectively. The haplotype Lr-32.0 (SLA-1*07:XX, SLA-2*02:XX, and SLA-3*04:XX) and Lr-0.23 (DRB1*10:XX, DQB1*06:XX, DQA* 01:XX) was the most common SLA class I and II haplotype, at 15.5 and 14.6%, respectively. Common class I and II haplotypes were also observed, which Lr-22.15 was the most predominant at 11.1%, followed by Lr-32.12 and Lr-4.2 at 10.8 and 7.9%, respectively. To our knowledge, this is the first report of SLA class I and II diversities in the commercial pigs in Southeast Asia. The information of the common SLA allele(s) in the population could facilitate swine genetic improvement and future vaccine design. |
| first_indexed | 2024-12-16T14:38:51Z |
| format | Article |
| id | doaj.art-ee687102b78e499aae493a25f33acc5f |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-16T14:38:51Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-ee687102b78e499aae493a25f33acc5f2022-12-21T22:28:02ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-04-01810.3389/fvets.2021.637682637682Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig PopulationsNavapon Techakriengkrai0Navapon Techakriengkrai1Navapon Techakriengkrai2Teerawut Nedumpun3Teerawut Nedumpun4William T. Golde5Sanipa Suradhat6Sanipa Suradhat7Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandDiagnosis and Monitoring of Animal Pathogens Research Unit, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Emerging Infectious Diseases in Animals, Chulalongkorn University (CU-EIDAs), Bangkok, ThailandDepartment of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Emerging Infectious Diseases in Animals, Chulalongkorn University (CU-EIDAs), Bangkok, ThailandDepartment of Vaccines and Diagnostics, Moredun Research Institute, Penicuik, United KingdomDepartment of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Emerging Infectious Diseases in Animals, Chulalongkorn University (CU-EIDAs), Bangkok, ThailandAmong swine genetic markers, the highly polymorphic swine leukocyte antigen (SLA) is one of the key determinants, associated with not only immune responses but also reproductive performance and meat quality. The objective of this study was to characterize the SLA class I and II diversities in the commercial pig populations. In this study, a total number of 158 pigs (126 gilts and 32 boars) were randomly selected from different breeding herds of five major pig-producing companies, which covered ~70% of Thai swine production. The results indicate that a moderate level of SLA diversity was maintained in the Thai swine population, despite the performance-oriented breeding scheme. The highly common SLA class I alleles were SLA-1*08:XX, SLA-2*02:XX, and SLA-3*04:XX at a combined frequency of 30.1, 18.4, and 34.5%, respectively, whereas DRB1*04:XX, DQB1*02:XX and DQA*02:XX were the common class II alleles at 22.8, 33.3, and 38.6%, respectively. The haplotype Lr-32.0 (SLA-1*07:XX, SLA-2*02:XX, and SLA-3*04:XX) and Lr-0.23 (DRB1*10:XX, DQB1*06:XX, DQA* 01:XX) was the most common SLA class I and II haplotype, at 15.5 and 14.6%, respectively. Common class I and II haplotypes were also observed, which Lr-22.15 was the most predominant at 11.1%, followed by Lr-32.12 and Lr-4.2 at 10.8 and 7.9%, respectively. To our knowledge, this is the first report of SLA class I and II diversities in the commercial pigs in Southeast Asia. The information of the common SLA allele(s) in the population could facilitate swine genetic improvement and future vaccine design.https://www.frontiersin.org/articles/10.3389/fvets.2021.637682/fullswine leukocyte antigenSLAclass Iclass IIdiversityhaplotype |
| spellingShingle | Navapon Techakriengkrai Navapon Techakriengkrai Navapon Techakriengkrai Teerawut Nedumpun Teerawut Nedumpun William T. Golde Sanipa Suradhat Sanipa Suradhat Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations Frontiers in Veterinary Science swine leukocyte antigen SLA class I class II diversity haplotype |
| title | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
| title_full | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
| title_fullStr | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
| title_full_unstemmed | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
| title_short | Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations |
| title_sort | diversity of the swine leukocyte antigen class i and ii in commercial pig populations |
| topic | swine leukocyte antigen SLA class I class II diversity haplotype |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2021.637682/full |
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