Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis
Abstract A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer’s disease (AD). Recent advancement in ultrasensitive protein assays has allowed the quantification of tau and phosphorylated tau proteins in periph...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40035-021-00234-5 |
| _version_ | 1818337247677644800 |
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| author | Xulong Ding Shuting Zhang Lijun Jiang Lu Wang Tao Li Peng Lei |
| author_facet | Xulong Ding Shuting Zhang Lijun Jiang Lu Wang Tao Li Peng Lei |
| author_sort | Xulong Ding |
| collection | DOAJ |
| description | Abstract A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer’s disease (AD). Recent advancement in ultrasensitive protein assays has allowed the quantification of tau and phosphorylated tau proteins in peripheral plasma. Here we identified 66 eligible studies reporting quantification of plasma tau and phosphorylated tau 181 (ptau181) using four ultrasensitive methods. Meta-analysis of these studies confirmed that the AD patients had significantly higher plasma tau and ptau181 levels compared with controls, and that the plasma tau and ptau181 could predict AD with high-accuracy area under curve of the Receiver Operating Characteristic. Therefore, plasma tau and plasma ptau181 can be considered as biomarkers for AD diagnosis. |
| first_indexed | 2024-12-13T14:52:11Z |
| format | Article |
| id | doaj.art-ee69379eb4ac45b08275bcefefb50a9e |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-12-13T14:52:11Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-ee69379eb4ac45b08275bcefefb50a9e2022-12-21T23:41:19ZengBMCTranslational Neurodegeneration2047-91582021-03-0110111410.1186/s40035-021-00234-5Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysisXulong Ding0Shuting Zhang1Lijun Jiang2Lu Wang3Tao Li4Peng Lei5Department of Neurology and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityMental Health Center and West China Brain Research Center, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityMental Health Center and West China Brain Research Center, West China Hospital, Sichuan UniversityDepartment of Neurology and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityAbstract A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer’s disease (AD). Recent advancement in ultrasensitive protein assays has allowed the quantification of tau and phosphorylated tau proteins in peripheral plasma. Here we identified 66 eligible studies reporting quantification of plasma tau and phosphorylated tau 181 (ptau181) using four ultrasensitive methods. Meta-analysis of these studies confirmed that the AD patients had significantly higher plasma tau and ptau181 levels compared with controls, and that the plasma tau and ptau181 could predict AD with high-accuracy area under curve of the Receiver Operating Characteristic. Therefore, plasma tau and plasma ptau181 can be considered as biomarkers for AD diagnosis.https://doi.org/10.1186/s40035-021-00234-5TauPhosphorylated tau 181Alzheimer’s diseaseSimoaIMREIMAF/a-EIMAF |
| spellingShingle | Xulong Ding Shuting Zhang Lijun Jiang Lu Wang Tao Li Peng Lei Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis Translational Neurodegeneration Tau Phosphorylated tau 181 Alzheimer’s disease Simoa IMR EIMAF/a-EIMAF |
| title | Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis |
| title_full | Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis |
| title_fullStr | Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis |
| title_full_unstemmed | Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis |
| title_short | Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer’s disease: a systematic review and meta-analysis |
| title_sort | ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in alzheimer s disease a systematic review and meta analysis |
| topic | Tau Phosphorylated tau 181 Alzheimer’s disease Simoa IMR EIMAF/a-EIMAF |
| url | https://doi.org/10.1186/s40035-021-00234-5 |
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