Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study
We conducted a retrospective cohort study to evaluate the subsequent colorectal cancer (CRC) risk for women with gynecologic malignancy using insurance claims data of Taiwan. We identified patients who survived cervical cancer (N = 25,370), endometrial cancer (N = 8149) and ovarian cancer (N = 7933)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/14/3127 |
| _version_ | 1797526894038482944 |
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| author | Szu-Chia Liao Hong-Zen Yeh Chi-Sen Chang Wei-Chih Chen Chih-Hsin Muo Fung-Chang Sung |
| author_facet | Szu-Chia Liao Hong-Zen Yeh Chi-Sen Chang Wei-Chih Chen Chih-Hsin Muo Fung-Chang Sung |
| author_sort | Szu-Chia Liao |
| collection | DOAJ |
| description | We conducted a retrospective cohort study to evaluate the subsequent colorectal cancer (CRC) risk for women with gynecologic malignancy using insurance claims data of Taiwan. We identified patients who survived cervical cancer (N = 25,370), endometrial cancer (N = 8149) and ovarian cancer (N = 7933) newly diagnosed from 1998 to 2010, and randomly selected comparisons (N = 165,808) without cancer, matched by age and diagnosis date. By the end of 2011, the incidence and hazard ratio (HR) of CRC were estimated. We found that CRC incidence rates were 1.26-, 2.20-, and 1.61-fold higher in women with cervical, endometrial and ovarian cancers, respectively, than in comparisons (1.09/1000 person–years). The CRC incidence increased with age. Higher adjusted HRs of CRC appeared within 3 years for women with endometrial and ovarian cancers, but not until the 4th to 7th years of follow up for cervical cancer survivals. Cancer treatments could reduce CRC risks, but not significantly. However, ovarian cancer patients receiving surgery alone had an incidence of 3.33/1000 person–years for CRC with an adjusted HR of 3.79 (95% CI 1.11–12.9) compared to patients without any treatment. In conclusion, gynecologic cancer patients are at an increased risk of developing CRC, sooner for those with endometrial or ovarian cancer than those with cervical cancer. |
| first_indexed | 2024-03-10T09:35:50Z |
| format | Article |
| id | doaj.art-ee6998fa1b544d949a132d1e2bbde65d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:35:50Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ee6998fa1b544d949a132d1e2bbde65d2023-11-22T04:07:06ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011014312710.3390/jcm10143127Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort StudySzu-Chia Liao0Hong-Zen Yeh1Chi-Sen Chang2Wei-Chih Chen3Chih-Hsin Muo4Fung-Chang Sung5Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung 407, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung 404, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung 404, TaiwanWe conducted a retrospective cohort study to evaluate the subsequent colorectal cancer (CRC) risk for women with gynecologic malignancy using insurance claims data of Taiwan. We identified patients who survived cervical cancer (N = 25,370), endometrial cancer (N = 8149) and ovarian cancer (N = 7933) newly diagnosed from 1998 to 2010, and randomly selected comparisons (N = 165,808) without cancer, matched by age and diagnosis date. By the end of 2011, the incidence and hazard ratio (HR) of CRC were estimated. We found that CRC incidence rates were 1.26-, 2.20-, and 1.61-fold higher in women with cervical, endometrial and ovarian cancers, respectively, than in comparisons (1.09/1000 person–years). The CRC incidence increased with age. Higher adjusted HRs of CRC appeared within 3 years for women with endometrial and ovarian cancers, but not until the 4th to 7th years of follow up for cervical cancer survivals. Cancer treatments could reduce CRC risks, but not significantly. However, ovarian cancer patients receiving surgery alone had an incidence of 3.33/1000 person–years for CRC with an adjusted HR of 3.79 (95% CI 1.11–12.9) compared to patients without any treatment. In conclusion, gynecologic cancer patients are at an increased risk of developing CRC, sooner for those with endometrial or ovarian cancer than those with cervical cancer.https://www.mdpi.com/2077-0383/10/14/3127colorectal cancergynecologic cancerretrospective cohort studycolonoscopy screening |
| spellingShingle | Szu-Chia Liao Hong-Zen Yeh Chi-Sen Chang Wei-Chih Chen Chih-Hsin Muo Fung-Chang Sung Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study Journal of Clinical Medicine colorectal cancer gynecologic cancer retrospective cohort study colonoscopy screening |
| title | Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study |
| title_full | Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study |
| title_fullStr | Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study |
| title_full_unstemmed | Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study |
| title_short | Colorectal Cancer Risk in Women with Gynecologic Cancers—A Population Retrospective Cohort Study |
| title_sort | colorectal cancer risk in women with gynecologic cancers a population retrospective cohort study |
| topic | colorectal cancer gynecologic cancer retrospective cohort study colonoscopy screening |
| url | https://www.mdpi.com/2077-0383/10/14/3127 |
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