Clinical Trial: Marine Lipid Suppositories as Laxatives
Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-09-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/10/9/2047 |
| _version_ | 1818035868647030784 |
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| author | Orri Thor Ormarsson Einar Stefansson Thorsteinn Loftsson Pall Hegli Moller Thormodur Geirsson Einar Stefan Bjornsson Tomas Jonsson |
| author_facet | Orri Thor Ormarsson Einar Stefansson Thorsteinn Loftsson Pall Hegli Moller Thormodur Geirsson Einar Stefan Bjornsson Tomas Jonsson |
| author_sort | Orri Thor Ormarsson |
| collection | DOAJ |
| description | Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. Results: No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). Conclusion: The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials. |
| first_indexed | 2024-12-10T07:01:54Z |
| format | Article |
| id | doaj.art-ee6ba98423a64ad5a3ab8724a2eefb62 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T07:01:54Z |
| publishDate | 2012-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ee6ba98423a64ad5a3ab8724a2eefb622022-12-22T01:58:19ZengMDPI AGMarine Drugs1660-33972012-09-011092047205410.3390/md10092047Clinical Trial: Marine Lipid Suppositories as LaxativesOrri Thor OrmarssonEinar StefanssonThorsteinn LoftssonPall Hegli MollerThormodur GeirssonEinar Stefan BjornssonTomas JonssonCod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. Results: No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). Conclusion: The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials.http://www.mdpi.com/1660-3397/10/9/2047suppositoriesointmentlaxativeomega-3 fatty acidclinical trial |
| spellingShingle | Orri Thor Ormarsson Einar Stefansson Thorsteinn Loftsson Pall Hegli Moller Thormodur Geirsson Einar Stefan Bjornsson Tomas Jonsson Clinical Trial: Marine Lipid Suppositories as Laxatives Marine Drugs suppositories ointment laxative omega-3 fatty acid clinical trial |
| title | Clinical Trial: Marine Lipid Suppositories as Laxatives |
| title_full | Clinical Trial: Marine Lipid Suppositories as Laxatives |
| title_fullStr | Clinical Trial: Marine Lipid Suppositories as Laxatives |
| title_full_unstemmed | Clinical Trial: Marine Lipid Suppositories as Laxatives |
| title_short | Clinical Trial: Marine Lipid Suppositories as Laxatives |
| title_sort | clinical trial marine lipid suppositories as laxatives |
| topic | suppositories ointment laxative omega-3 fatty acid clinical trial |
| url | http://www.mdpi.com/1660-3397/10/9/2047 |
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