Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso
Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained marker...
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MDPI AG
2019-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/6/554 |
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| author | Chloé Dimeglio Dramane Kania Judith Mbombi Mantono Thérèse Kagoné Sylvie Zida Souleymane Tassembedo Amadou Dicko Bachirou Tinto Seydou Yaro Hervé Hien Jérémi Rouamba Brice Bicaba Isaïe Medah Nicolas Meda Oumar Traoré Edouard Tuaillon Florence Abravanel Jacques Izopet |
| author_facet | Chloé Dimeglio Dramane Kania Judith Mbombi Mantono Thérèse Kagoné Sylvie Zida Souleymane Tassembedo Amadou Dicko Bachirou Tinto Seydou Yaro Hervé Hien Jérémi Rouamba Brice Bicaba Isaïe Medah Nicolas Meda Oumar Traoré Edouard Tuaillon Florence Abravanel Jacques Izopet |
| author_sort | Chloé Dimeglio |
| collection | DOAJ |
| description | Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country. |
| first_indexed | 2024-12-19T03:27:55Z |
| format | Article |
| id | doaj.art-ee6c3f25c9ad48a8b3958cd0228c4f76 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-19T03:27:55Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ee6c3f25c9ad48a8b3958cd0228c4f762022-12-21T20:37:33ZengMDPI AGViruses1999-49152019-06-0111655410.3390/v11060554v11060554Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina FasoChloé Dimeglio0Dramane Kania1Judith Mbombi Mantono2Thérèse Kagoné3Sylvie Zida4Souleymane Tassembedo5Amadou Dicko6Bachirou Tinto7Seydou Yaro8Hervé Hien9Jérémi Rouamba10Brice Bicaba11Isaïe Medah12Nicolas Meda13Oumar Traoré14Edouard Tuaillon15Florence Abravanel16Jacques Izopet17Laboratoire de virologie, Centre national de référence du virus de l’hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoCentre MURAZ, Bobo-Dioulasso, Burkina FasoInstitut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina FasoMinistère de la Santé, Ouagadougou, Burkina FasoMinistère de la Santé, Ouagadougou, Burkina FasoAgence nationale de biosécurité, Ouagadougou, Burkina FasoPathogenesis and Control of Chronic Infections., Etablissement Français du Sang, CHU Montpellier, INSERM, University of Montpellier, 34090 Montpellier, FranceLaboratoire de virologie, Centre national de référence du virus de l’hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceLaboratoire de virologie, Centre national de référence du virus de l’hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceHepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.https://www.mdpi.com/1999-4915/11/6/554Burkina Fasohepatitis E virusepidemiologyrisk factors |
| spellingShingle | Chloé Dimeglio Dramane Kania Judith Mbombi Mantono Thérèse Kagoné Sylvie Zida Souleymane Tassembedo Amadou Dicko Bachirou Tinto Seydou Yaro Hervé Hien Jérémi Rouamba Brice Bicaba Isaïe Medah Nicolas Meda Oumar Traoré Edouard Tuaillon Florence Abravanel Jacques Izopet Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso Viruses Burkina Faso hepatitis E virus epidemiology risk factors |
| title | Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso |
| title_full | Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso |
| title_fullStr | Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso |
| title_full_unstemmed | Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso |
| title_short | Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso |
| title_sort | hepatitis e virus infections among patients with acute febrile jaundice in burkina faso |
| topic | Burkina Faso hepatitis E virus epidemiology risk factors |
| url | https://www.mdpi.com/1999-4915/11/6/554 |
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