Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites – case report and a literature review
In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment ofthe KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results ofthe analysis of several studies revealed a high rate of compliance o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2010-04-01
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| Series: | Folia Histochemica et Cytobiologica |
| Subjects: | |
| Online Access: | http://www.fhc.viamedica.pl/darmowy_pdf.phtml?indeks=128&indeks_art=1288 |
| Summary: | In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment ofthe KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results ofthe analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatictumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located inthe colon and metastatic changes in the liver. |
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| ISSN: | 0239-8508 1897-5631 |