Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data
Method development has always been and will continue to be a core driving force of microbiome science. In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by three key changes in both ways of thinking and technological platforms: ① a shift...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809917301595 |
| _version_ | 1818353665402994688 |
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| author | Jian Xu Bo Ma Xiaoquan Su Shi Huang Xin Xu Xuedong Zhou Wei E. Huang Rob Knight |
| author_facet | Jian Xu Bo Ma Xiaoquan Su Shi Huang Xin Xu Xuedong Zhou Wei E. Huang Rob Knight |
| author_sort | Jian Xu |
| collection | DOAJ |
| description | Method development has always been and will continue to be a core driving force of microbiome science. In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by three key changes in both ways of thinking and technological platforms: ① a shift from dissecting microbiota structure by sequencing to tracking microbiota state, function, and intercellular interaction via imaging; ② a shift from interrogating a consortium or population of cells to probing individual cells; and ③ a shift from microbiome data analysis to microbiome data science. Some of the recent method-development efforts by Chinese microbiome scientists and their international collaborators that underlie these technological trends are highlighted here. It is our belief that the China Microbiome Initiative has the opportunity to deliver outstanding “Made-in-China” tools to the international research community, by building an ambitious, competitive, and collaborative program at the forefront of method development for microbiome science. |
| first_indexed | 2024-12-13T19:13:08Z |
| format | Article |
| id | doaj.art-ee6e12655d034aa8ba39103890cbd941 |
| institution | Directory Open Access Journal |
| issn | 2095-8099 |
| language | English |
| last_indexed | 2024-12-13T19:13:08Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering |
| spelling | doaj.art-ee6e12655d034aa8ba39103890cbd9412022-12-21T23:34:22ZengElsevierEngineering2095-80992017-02-0131667010.1016/J.ENG.2017.01.020Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big DataJian Xu0Bo Ma1Xiaoquan Su2Shi Huang3Xin Xu4Xuedong Zhou5Wei E. Huang6Rob Knight7Single-Cell Center, CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, ChinaSingle-Cell Center, CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, ChinaSingle-Cell Center, CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, ChinaSingle-Cell Center, CAS Key Laboratory of Biofuels, Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, UKCenter for Microbiome Innovation, Department of Pediatrics, Department of Computer Science and Engineering, University of California, San Diego, CA 92093, USAMethod development has always been and will continue to be a core driving force of microbiome science. In this perspective, we argue that in the next decade, method development in microbiome analysis will be driven by three key changes in both ways of thinking and technological platforms: ① a shift from dissecting microbiota structure by sequencing to tracking microbiota state, function, and intercellular interaction via imaging; ② a shift from interrogating a consortium or population of cells to probing individual cells; and ③ a shift from microbiome data analysis to microbiome data science. Some of the recent method-development efforts by Chinese microbiome scientists and their international collaborators that underlie these technological trends are highlighted here. It is our belief that the China Microbiome Initiative has the opportunity to deliver outstanding “Made-in-China” tools to the international research community, by building an ambitious, competitive, and collaborative program at the forefront of method development for microbiome science.http://www.sciencedirect.com/science/article/pii/S2095809917301595MicrobiomeMethod developmentSingle-cell analysisBig dataChina Microbiome Initiative |
| spellingShingle | Jian Xu Bo Ma Xiaoquan Su Shi Huang Xin Xu Xuedong Zhou Wei E. Huang Rob Knight Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data Engineering Microbiome Method development Single-cell analysis Big data China Microbiome Initiative |
| title | Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data |
| title_full | Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data |
| title_fullStr | Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data |
| title_full_unstemmed | Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data |
| title_short | Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data |
| title_sort | emerging trends for microbiome analysis from single cell functional imaging to microbiome big data |
| topic | Microbiome Method development Single-cell analysis Big data China Microbiome Initiative |
| url | http://www.sciencedirect.com/science/article/pii/S2095809917301595 |
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