Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it>
<p>Abstract</p> <p>One of the hallmarks of bacterial survival is their ability to adapt rapidly to changing environmental conditions. Niche adaptation is a response to the signals received that are relayed, often to regulators that modulate gene expression. In the post-genomic era,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2009-07-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/3/4/349 |
| _version_ | 1811184492349489152 |
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| author | Balasubramanian Deepak Mathee Kalai |
| author_facet | Balasubramanian Deepak Mathee Kalai |
| author_sort | Balasubramanian Deepak |
| collection | DOAJ |
| description | <p>Abstract</p> <p>One of the hallmarks of bacterial survival is their ability to adapt rapidly to changing environmental conditions. Niche adaptation is a response to the signals received that are relayed, often to regulators that modulate gene expression. In the post-genomic era, DNA microarrays are used to study the dynamics of gene expression on a global scale. Numerous studies have used <it>Pseudomonas aeruginosa</it>--a Gram-negative environmental and opportunistic human pathogenic bacterium--as the model organism in whole-genome transcriptome analysis. This paper reviews the transcriptome studies that have led to immense advances in our understanding of the biology of this intractable human pathogen. Comparative analysis of 23 <it>P. aeruginosa </it>transcriptome studies has led to the identification of a unique set of genes that are signal specific and a core set that is differentially regulated. The 303 genes in the core set are involved in bacterial homeostasis, making them attractive therapeutic targets.</p> |
| first_indexed | 2024-04-11T13:13:09Z |
| format | Article |
| id | doaj.art-ee6f24f794ea4822b200a94a90cabf83 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-11T13:13:09Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-ee6f24f794ea4822b200a94a90cabf832022-12-22T04:22:28ZengBMCHuman Genomics1479-73642009-07-013434936110.1186/1479-7364-3-4-361Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it>Balasubramanian DeepakMathee Kalai<p>Abstract</p> <p>One of the hallmarks of bacterial survival is their ability to adapt rapidly to changing environmental conditions. Niche adaptation is a response to the signals received that are relayed, often to regulators that modulate gene expression. In the post-genomic era, DNA microarrays are used to study the dynamics of gene expression on a global scale. Numerous studies have used <it>Pseudomonas aeruginosa</it>--a Gram-negative environmental and opportunistic human pathogenic bacterium--as the model organism in whole-genome transcriptome analysis. This paper reviews the transcriptome studies that have led to immense advances in our understanding of the biology of this intractable human pathogen. Comparative analysis of 23 <it>P. aeruginosa </it>transcriptome studies has led to the identification of a unique set of genes that are signal specific and a core set that is differentially regulated. The 303 genes in the core set are involved in bacterial homeostasis, making them attractive therapeutic targets.</p>http://www.humgenomics.com/content/3/4/349alginatebacteriabiofilmcomparative transcriptomecopperiron limitationmicroarrayosmotic stressoxidative stresspathogenesisPCPPseudomonas aeruginosasulphatequorum sensing |
| spellingShingle | Balasubramanian Deepak Mathee Kalai Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it> Human Genomics alginate bacteria biofilm comparative transcriptome copper iron limitation microarray osmotic stress oxidative stress pathogenesis PCP Pseudomonas aeruginosa sulphate quorum sensing |
| title | Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it> |
| title_full | Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it> |
| title_fullStr | Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it> |
| title_full_unstemmed | Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it> |
| title_short | Comparative transcriptome analyses of <it>Pseudomonas aeruginosa</it> |
| title_sort | comparative transcriptome analyses of it pseudomonas aeruginosa it |
| topic | alginate bacteria biofilm comparative transcriptome copper iron limitation microarray osmotic stress oxidative stress pathogenesis PCP Pseudomonas aeruginosa sulphate quorum sensing |
| url | http://www.humgenomics.com/content/3/4/349 |
| work_keys_str_mv | AT balasubramaniandeepak comparativetranscriptomeanalysesofitpseudomonasaeruginosait AT matheekalai comparativetranscriptomeanalysesofitpseudomonasaeruginosait |