N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis
Hepatitis B Virus (HBV) glycobiology has been an area of intensive research in the last decades and continues to be an attractive topic due to the multiple roles that N-glycosylation in particular plays in the virus life-cycle and its interaction with the host that are still being discovered. The th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/6/1404 |
| _version_ | 1797566125453606912 |
|---|---|
| author | Mihaela-Olivia Dobrica Catalin Lazar Norica Branza-Nichita |
| author_facet | Mihaela-Olivia Dobrica Catalin Lazar Norica Branza-Nichita |
| author_sort | Mihaela-Olivia Dobrica |
| collection | DOAJ |
| description | Hepatitis B Virus (HBV) glycobiology has been an area of intensive research in the last decades and continues to be an attractive topic due to the multiple roles that N-glycosylation in particular plays in the virus life-cycle and its interaction with the host that are still being discovered. The three HBV envelope glycoproteins, small (S), medium (M) and large (L) share a very peculiar N-glycosylation pattern, which distinctly regulates their folding, degradation, assembly, intracellular trafficking and antigenic properties. In addition, recent findings indicate important roles of N-linked oligosaccharides in viral pathogenesis and evasion of the immune system surveillance. This review focuses on N-glycosylation’s contribution to HBV infection and disease, with implications for development of improved vaccines and antiviral therapies. |
| first_indexed | 2024-03-10T19:22:19Z |
| format | Article |
| id | doaj.art-ee72112b47204d668b536d4adf03afa2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:22:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ee72112b47204d668b536d4adf03afa22023-11-20T02:54:17ZengMDPI AGCells2073-44092020-06-0196140410.3390/cells9061404N-Glycosylation and N-Glycan Processing in HBV Biology and PathogenesisMihaela-Olivia Dobrica0Catalin Lazar1Norica Branza-Nichita2Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, Sector 6, 060031 Bucharest, RomaniaInstitute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, Sector 6, 060031 Bucharest, RomaniaInstitute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, Sector 6, 060031 Bucharest, RomaniaHepatitis B Virus (HBV) glycobiology has been an area of intensive research in the last decades and continues to be an attractive topic due to the multiple roles that N-glycosylation in particular plays in the virus life-cycle and its interaction with the host that are still being discovered. The three HBV envelope glycoproteins, small (S), medium (M) and large (L) share a very peculiar N-glycosylation pattern, which distinctly regulates their folding, degradation, assembly, intracellular trafficking and antigenic properties. In addition, recent findings indicate important roles of N-linked oligosaccharides in viral pathogenesis and evasion of the immune system surveillance. This review focuses on N-glycosylation’s contribution to HBV infection and disease, with implications for development of improved vaccines and antiviral therapies.https://www.mdpi.com/2073-4409/9/6/1404HBVglycosylationfoldingvaccineimmune responseHCC |
| spellingShingle | Mihaela-Olivia Dobrica Catalin Lazar Norica Branza-Nichita N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis Cells HBV glycosylation folding vaccine immune response HCC |
| title | N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis |
| title_full | N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis |
| title_fullStr | N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis |
| title_full_unstemmed | N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis |
| title_short | N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis |
| title_sort | n glycosylation and n glycan processing in hbv biology and pathogenesis |
| topic | HBV glycosylation folding vaccine immune response HCC |
| url | https://www.mdpi.com/2073-4409/9/6/1404 |
| work_keys_str_mv | AT mihaelaoliviadobrica nglycosylationandnglycanprocessinginhbvbiologyandpathogenesis AT catalinlazar nglycosylationandnglycanprocessinginhbvbiologyandpathogenesis AT noricabranzanichita nglycosylationandnglycanprocessinginhbvbiologyandpathogenesis |