Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

Rosuvastatin is a well-known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery disease prevention. There is a substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to a variation in the correspon...

Full description

Bibliographic Details
Main Authors: Anne Michelli Reis Silveira, Gustavo Henrique Bueno Duarte, Anna Maria Alves de Piloto Fernandes, Pedro Henrique Dias Garcia, Nelson Rogerio Vieira, Marcia Aparecida Antonio, Patricia de Oliveira Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
personalized medicine
metabolomics
rosuvastatin
prediction
machine learning
pharmacometabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.752960/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.752960/full

Similar Items