Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries
Abstract To investigate the effect and safety of recanalization surgery for non-acute occlusion of large intracranial arteries and factors affecting clincial outcomes. Patients with non-acute occlusion of internal carotid artery (ICA), middle cerebral artery (MCA), and vertebrobasilar artery (VBA) t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31313-4 |
| _version_ | 1797864868865376256 |
|---|---|
| author | Jinchao Xia Huili Gao Kun Zhang Bulang Gao Tianxiao Li Ziliang Wang |
| author_facet | Jinchao Xia Huili Gao Kun Zhang Bulang Gao Tianxiao Li Ziliang Wang |
| author_sort | Jinchao Xia |
| collection | DOAJ |
| description | Abstract To investigate the effect and safety of recanalization surgery for non-acute occlusion of large intracranial arteries and factors affecting clincial outcomes. Patients with non-acute occlusion of internal carotid artery (ICA), middle cerebral artery (MCA), and vertebrobasilar artery (VBA) treated with recanalization were retrospectively enrolled. The clinical and angiographic data were analyzed. 177 patients were enrolled, including 67 patients with intracranial ICA occlusion, 52 with MCA occlusion, and 58 with VBA occlusion. Successful recanalization was achieved in 152 (85.9%) patients. Complications occurred in 15 patients (8.5%). Followed up for 3–7 months, the 90 day mRS was significantly improved compared with that before the procedure. Among 152 patients with successful recanalization, eight patients experienced reocclusion (5.3%), and 11 patients experienced restenosis (7.2%). Successful recanalization was significantly (P < 0.05) associated with occlusion duration, calcification or angulation of the occluded segment. Complications were significantly (P < 0.05) associated with location of occlusion, hyperlipidemia, and patients’ height. Restentosis or reocclusion at follow-up was significantly (P < 0.05) associated with complications and mRS at 90 days. The significant (P < 0.05) independent risk factors were angulation and calcification for successful recanalization, hyperlipidemia for complications, and mRS at 90 days for restenosis or reocclusion at follow-up. Recanalization surgery may be a safe and effective approach for patients with non-acute symptomatic occlusion of large intracranial arteries, and factors significantly independently associated with successful recanalization, periprocedural complications and restenosis or reocclusion after surgery have been identified for future reference to improve clinical outcomes. |
| first_indexed | 2024-04-09T23:00:07Z |
| format | Article |
| id | doaj.art-ee726fac0c964dccb4b2619396971671 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:00:07Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ee726fac0c964dccb4b26193969716712023-03-22T11:05:10ZengNature PortfolioScientific Reports2045-23222023-03-0113111210.1038/s41598-023-31313-4Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteriesJinchao Xia0Huili Gao1Kun Zhang2Bulang Gao3Tianxiao Li4Ziliang Wang5Stroke Center, Henan Provincial People’s Hospital, Zhengzhou University and Henan UniversityStroke Center, Henan Provincial People’s Hospital, Zhengzhou University and Henan UniversityStroke Center, Henan Provincial People’s Hospital, Zhengzhou University and Henan UniversityStroke Center, Henan Provincial People’s Hospital, Zhengzhou University and Henan UniversityStroke Center, Henan Provincial People’s Hospital, Zhengzhou University and Henan UniversityStroke Center, Henan Provincial People’s Hospital, Zhengzhou University and Henan UniversityAbstract To investigate the effect and safety of recanalization surgery for non-acute occlusion of large intracranial arteries and factors affecting clincial outcomes. Patients with non-acute occlusion of internal carotid artery (ICA), middle cerebral artery (MCA), and vertebrobasilar artery (VBA) treated with recanalization were retrospectively enrolled. The clinical and angiographic data were analyzed. 177 patients were enrolled, including 67 patients with intracranial ICA occlusion, 52 with MCA occlusion, and 58 with VBA occlusion. Successful recanalization was achieved in 152 (85.9%) patients. Complications occurred in 15 patients (8.5%). Followed up for 3–7 months, the 90 day mRS was significantly improved compared with that before the procedure. Among 152 patients with successful recanalization, eight patients experienced reocclusion (5.3%), and 11 patients experienced restenosis (7.2%). Successful recanalization was significantly (P < 0.05) associated with occlusion duration, calcification or angulation of the occluded segment. Complications were significantly (P < 0.05) associated with location of occlusion, hyperlipidemia, and patients’ height. Restentosis or reocclusion at follow-up was significantly (P < 0.05) associated with complications and mRS at 90 days. The significant (P < 0.05) independent risk factors were angulation and calcification for successful recanalization, hyperlipidemia for complications, and mRS at 90 days for restenosis or reocclusion at follow-up. Recanalization surgery may be a safe and effective approach for patients with non-acute symptomatic occlusion of large intracranial arteries, and factors significantly independently associated with successful recanalization, periprocedural complications and restenosis or reocclusion after surgery have been identified for future reference to improve clinical outcomes.https://doi.org/10.1038/s41598-023-31313-4 |
| spellingShingle | Jinchao Xia Huili Gao Kun Zhang Bulang Gao Tianxiao Li Ziliang Wang Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries Scientific Reports |
| title | Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries |
| title_full | Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries |
| title_fullStr | Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries |
| title_full_unstemmed | Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries |
| title_short | Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries |
| title_sort | effects of endovascular recanalization on symptomatic non acute occlusion of intracranial arteries |
| url | https://doi.org/10.1038/s41598-023-31313-4 |
| work_keys_str_mv | AT jinchaoxia effectsofendovascularrecanalizationonsymptomaticnonacuteocclusionofintracranialarteries AT huiligao effectsofendovascularrecanalizationonsymptomaticnonacuteocclusionofintracranialarteries AT kunzhang effectsofendovascularrecanalizationonsymptomaticnonacuteocclusionofintracranialarteries AT bulanggao effectsofendovascularrecanalizationonsymptomaticnonacuteocclusionofintracranialarteries AT tianxiaoli effectsofendovascularrecanalizationonsymptomaticnonacuteocclusionofintracranialarteries AT ziliangwang effectsofendovascularrecanalizationonsymptomaticnonacuteocclusionofintracranialarteries |