Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus
Abstract In the present study, anthelmintic activities of Arundo (A.) donax L., Areca (Ar.) catechu L., and Ferula (F.) assa-foetida L. were determined. Leaves of A. donax L., latex of F. assa-foetida L. and seeds of Ar. catechu L. in different solvent fractions were subjected to in vitro (egg hatch...
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Colégio Brasileiro de Parasitologia Veterinaria
2021-05-01
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| Series: | Revista Brasileira de Parasitologia Veterinária |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612021000200312&tlng=en |
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| author | Syed Nadeem Badar Zafar Iqbal Muhammad Sohail Sajid Hafiz Muhammad Rizwan Muhammad Shareef Muhammad Abdullah Malik Muhammad Nisar Khan |
| author_facet | Syed Nadeem Badar Zafar Iqbal Muhammad Sohail Sajid Hafiz Muhammad Rizwan Muhammad Shareef Muhammad Abdullah Malik Muhammad Nisar Khan |
| author_sort | Syed Nadeem Badar |
| collection | DOAJ |
| description | Abstract In the present study, anthelmintic activities of Arundo (A.) donax L., Areca (Ar.) catechu L., and Ferula (F.) assa-foetida L. were determined. Leaves of A. donax L., latex of F. assa-foetida L. and seeds of Ar. catechu L. in different solvent fractions were subjected to in vitro (egg hatch assay; EHA, and adult motility assay; AMA) and in vivo (faecal egg count reduction test; FECRT) tests of anthelmintic activity using Haemonchus contortus model. In the AMA, crude aqueous methanol extracts (CAME) and ethyl acetate fractions of F. assa-foetida at 10 hr post-treatment showed maximum mortality of H. contortus at 12.5-50 mg mL-1. In the EHA, CAME of F. assa-foetida was identified as a potent ovicide based on its low LC50 (16.9 µg mL-1), followed in order by Ar. catechu and A. donax. Results from the FECRT also showed the extract of F. assa-foetida L. to be more effective than those of Ar. catechu L. and A. donax L., against the gastrointestinal parasitic nematodes. Chloroform and ethyl acetate fractions showed better anthelmintic activities against the adult worms in vitro, while CAME of these plants were better than their crude powders in vivo. It is recommended to document and investigate indigenous knowledge of possible medicinal plants to plan scientific trials that may justify their endorsement. |
| first_indexed | 2024-12-19T16:59:48Z |
| format | Article |
| id | doaj.art-ee76195a7a544de9a699a91136ef9717 |
| institution | Directory Open Access Journal |
| issn | 1984-2961 |
| language | English |
| last_indexed | 2024-12-19T16:59:48Z |
| publishDate | 2021-05-01 |
| publisher | Colégio Brasileiro de Parasitologia Veterinaria |
| record_format | Article |
| series | Revista Brasileira de Parasitologia Veterinária |
| spelling | doaj.art-ee76195a7a544de9a699a91136ef97172022-12-21T20:13:20ZengColégio Brasileiro de Parasitologia VeterinariaRevista Brasileira de Parasitologia Veterinária1984-29612021-05-0130210.1590/s1984-29612021028Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortusSyed Nadeem BadarZafar IqbalMuhammad Sohail Sajidhttps://orcid.org/0000-0002-3863-6480Hafiz Muhammad Rizwanhttps://orcid.org/0000-0002-6048-7610Muhammad ShareefMuhammad Abdullah MalikMuhammad Nisar KhanAbstract In the present study, anthelmintic activities of Arundo (A.) donax L., Areca (Ar.) catechu L., and Ferula (F.) assa-foetida L. were determined. Leaves of A. donax L., latex of F. assa-foetida L. and seeds of Ar. catechu L. in different solvent fractions were subjected to in vitro (egg hatch assay; EHA, and adult motility assay; AMA) and in vivo (faecal egg count reduction test; FECRT) tests of anthelmintic activity using Haemonchus contortus model. In the AMA, crude aqueous methanol extracts (CAME) and ethyl acetate fractions of F. assa-foetida at 10 hr post-treatment showed maximum mortality of H. contortus at 12.5-50 mg mL-1. In the EHA, CAME of F. assa-foetida was identified as a potent ovicide based on its low LC50 (16.9 µg mL-1), followed in order by Ar. catechu and A. donax. Results from the FECRT also showed the extract of F. assa-foetida L. to be more effective than those of Ar. catechu L. and A. donax L., against the gastrointestinal parasitic nematodes. Chloroform and ethyl acetate fractions showed better anthelmintic activities against the adult worms in vitro, while CAME of these plants were better than their crude powders in vivo. It is recommended to document and investigate indigenous knowledge of possible medicinal plants to plan scientific trials that may justify their endorsement.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612021000200312&tlng=enArundo donax L.Areca catechu L.Ferula assa-foetida L.Haemonchus contortusin vivoin vitro |
| spellingShingle | Syed Nadeem Badar Zafar Iqbal Muhammad Sohail Sajid Hafiz Muhammad Rizwan Muhammad Shareef Muhammad Abdullah Malik Muhammad Nisar Khan Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus Revista Brasileira de Parasitologia Veterinária Arundo donax L. Areca catechu L. Ferula assa-foetida L. Haemonchus contortus in vivo in vitro |
| title | Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus |
| title_full | Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus |
| title_fullStr | Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus |
| title_full_unstemmed | Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus |
| title_short | Comparative anthelmintic efficacy of Arundo donax, Areca catechu, and Ferula assa-foetida against Haemonchus contortus |
| title_sort | comparative anthelmintic efficacy of arundo donax areca catechu and ferula assa foetida against haemonchus contortus |
| topic | Arundo donax L. Areca catechu L. Ferula assa-foetida L. Haemonchus contortus in vivo in vitro |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612021000200312&tlng=en |
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