Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective
The neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells differentiate at their final destinations and proliferate into different tissues whose activity is reduced by...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/1/2 |
| _version_ | 1797543887527477248 |
|---|---|
| author | Goran Šimić Vana Vukić Janja Kopić Željka Krsnik Patrick R. Hof |
| author_facet | Goran Šimić Vana Vukić Janja Kopić Željka Krsnik Patrick R. Hof |
| author_sort | Goran Šimić |
| collection | DOAJ |
| description | The neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells differentiate at their final destinations and proliferate into different tissues whose activity is reduced by domestication. Comparing the phenotypic characteristics of modern and prehistoric man, it is clear that during their recent evolutionary past, humans also went through a process of self-domestication with a simultaneous prolongation of the period of socialization. This has led to the development of social abilities and skills, especially language, as well as neoteny. Disorders of neural crest cell development and migration lead to many different conditions such as Waardenburg syndrome, Hirschsprung disease, fetal alcohol syndrome, DiGeorge and Treacher-Collins syndrome, for which the mechanisms are already relatively well-known. However, for others, such as Williams-Beuren syndrome and schizophrenia that have the characteristics of hyperdomestication, and autism spectrum disorders, and 7dupASD syndrome that have the characteristics of hypodomestication, much less is known. Thus, deciphering the biological determinants of disordered self-domestication has great potential for elucidating the normal and disturbed ontogenesis of humans, as well as for the understanding of evolution of mammals in general. |
| first_indexed | 2024-03-10T13:51:51Z |
| format | Article |
| id | doaj.art-ee7674aa72244fe898ce40001cb4d53a |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T13:51:51Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ee7674aa72244fe898ce40001cb4d53a2023-11-21T02:04:48ZengMDPI AGBiomolecules2218-273X2020-12-01111210.3390/biom11010002Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary PerspectiveGoran Šimić0Vana Vukić1Janja Kopić2Željka Krsnik3Patrick R. Hof4Department of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, CroatiaDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, CroatiaDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, CroatiaDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, CroatiaNash Family Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer’s disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAThe neural crest hypothesis states that the phenotypic features of the domestication syndrome are due to a reduced number or disruption of neural crest cells (NCCs) migration, as these cells differentiate at their final destinations and proliferate into different tissues whose activity is reduced by domestication. Comparing the phenotypic characteristics of modern and prehistoric man, it is clear that during their recent evolutionary past, humans also went through a process of self-domestication with a simultaneous prolongation of the period of socialization. This has led to the development of social abilities and skills, especially language, as well as neoteny. Disorders of neural crest cell development and migration lead to many different conditions such as Waardenburg syndrome, Hirschsprung disease, fetal alcohol syndrome, DiGeorge and Treacher-Collins syndrome, for which the mechanisms are already relatively well-known. However, for others, such as Williams-Beuren syndrome and schizophrenia that have the characteristics of hyperdomestication, and autism spectrum disorders, and 7dupASD syndrome that have the characteristics of hypodomestication, much less is known. Thus, deciphering the biological determinants of disordered self-domestication has great potential for elucidating the normal and disturbed ontogenesis of humans, as well as for the understanding of evolution of mammals in general.https://www.mdpi.com/2218-273X/11/1/2chemoattractantschemorepellentsepithelial-mesenchymal transition (EMT)extracellular matrix moleculesfibroblast growth factor (FGF)methyl-CpG-binding protein 2 (MeCP2) |
| spellingShingle | Goran Šimić Vana Vukić Janja Kopić Željka Krsnik Patrick R. Hof Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective Biomolecules chemoattractants chemorepellents epithelial-mesenchymal transition (EMT) extracellular matrix molecules fibroblast growth factor (FGF) methyl-CpG-binding protein 2 (MeCP2) |
| title | Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective |
| title_full | Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective |
| title_fullStr | Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective |
| title_full_unstemmed | Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective |
| title_short | Molecules, Mechanisms, and Disorders of Self-Domestication: Keys for Understanding Emotional and Social Communication from an Evolutionary Perspective |
| title_sort | molecules mechanisms and disorders of self domestication keys for understanding emotional and social communication from an evolutionary perspective |
| topic | chemoattractants chemorepellents epithelial-mesenchymal transition (EMT) extracellular matrix molecules fibroblast growth factor (FGF) methyl-CpG-binding protein 2 (MeCP2) |
| url | https://www.mdpi.com/2218-273X/11/1/2 |
| work_keys_str_mv | AT goransimic moleculesmechanismsanddisordersofselfdomesticationkeysforunderstandingemotionalandsocialcommunicationfromanevolutionaryperspective AT vanavukic moleculesmechanismsanddisordersofselfdomesticationkeysforunderstandingemotionalandsocialcommunicationfromanevolutionaryperspective AT janjakopic moleculesmechanismsanddisordersofselfdomesticationkeysforunderstandingemotionalandsocialcommunicationfromanevolutionaryperspective AT zeljkakrsnik moleculesmechanismsanddisordersofselfdomesticationkeysforunderstandingemotionalandsocialcommunicationfromanevolutionaryperspective AT patrickrhof moleculesmechanismsanddisordersofselfdomesticationkeysforunderstandingemotionalandsocialcommunicationfromanevolutionaryperspective |