High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles
(1) Background: Magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles have great potential for biomedical applications, including hyperthermia and magnetic resonance imaging. In this study, we aimed to identify the biological activity of nanoconjugates composed of superparama...
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MDPI AG
2023-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/5/1523 |
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| author | Xuan-Hai Do Tu Dac Nguyen Thi Thu Huong Le Thuy Thanh To Thi Van Khanh Bui Nam Hong Pham Khanh Lam Thi My Nhung Hoang Phuong Thu Ha |
| author_facet | Xuan-Hai Do Tu Dac Nguyen Thi Thu Huong Le Thuy Thanh To Thi Van Khanh Bui Nam Hong Pham Khanh Lam Thi My Nhung Hoang Phuong Thu Ha |
| author_sort | Xuan-Hai Do |
| collection | DOAJ |
| description | (1) Background: Magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles have great potential for biomedical applications, including hyperthermia and magnetic resonance imaging. In this study, we aimed to identify the biological activity of nanoconjugates composed of superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with alginate and curcumin (Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG) in cancer cells. (2) Methods: The nanoparticles were evaluated for the biocompatibility and toxicity on mice. The MRI enhancement and hyperthermia capacities of Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG were determined in both in vitro and in vivo sarcoma models. (3) Results: The results show that the magnetite nanoparticles exhibit high biocompatibility and low toxicity in mice at Fe<sub>3</sub>O<sub>4</sub> concentrations up to 120 mg/kg when administered via intravenous injection. The Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG nanoparticles enhance the magnetic resonance imaging contrast in cell cultures and tumor-bearing Swiss mice. The autofluorescence of curcumin also allowed us to observe the penetration of the nanoparticles into sarcoma 180 cells. In particular, the nanoconjugates synergistically inhibit the growth of sarcoma 180 tumors via magnetic heating and the anticancer effects of curcumin, both in vitro and in vivo. (4) Conclusions: Our study reveals that Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG has a high potential for medicinal applications and should be further developed for cancer diagnosis and treatment. |
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| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T03:24:53Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-ee77af892cee4098892c84aa90f4a5802023-11-18T02:52:49ZengMDPI AGPharmaceutics1999-49232023-05-01155152310.3390/pharmaceutics15051523High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> NanoparticlesXuan-Hai Do0Tu Dac Nguyen1Thi Thu Huong Le2Thuy Thanh To3Thi Van Khanh Bui4Nam Hong Pham5Khanh Lam6Thi My Nhung Hoang7Phuong Thu Ha8Department of Practical and Experimental Surgery, Vietnam Military Medical University, 160 Phung Hung Road, Ha Dong District, Hanoi 10000, VietnamVinmec Center of Applied Sciences, Regenerative Medicine, and Advance Technologies, 458 Minh Khai, Hai Ba Trung District, Hanoi 10000, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 10000, VietnamFaculty of Biology, VNU University of Science, Hanoi, 334 Nguyen Trai Road, Thanh Xuan District, Hanoi 10000, VietnamFaculty of Biology, VNU University of Science, Hanoi, 334 Nguyen Trai Road, Thanh Xuan District, Hanoi 10000, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 10000, Vietnam108 Military Central Hospital, 1 Tran Hung Dao Road, Hai Ba Trung District, Hanoi 10000, VietnamVinmec Center of Applied Sciences, Regenerative Medicine, and Advance Technologies, 458 Minh Khai, Hai Ba Trung District, Hanoi 10000, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 10000, Vietnam(1) Background: Magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles have great potential for biomedical applications, including hyperthermia and magnetic resonance imaging. In this study, we aimed to identify the biological activity of nanoconjugates composed of superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with alginate and curcumin (Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG) in cancer cells. (2) Methods: The nanoparticles were evaluated for the biocompatibility and toxicity on mice. The MRI enhancement and hyperthermia capacities of Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG were determined in both in vitro and in vivo sarcoma models. (3) Results: The results show that the magnetite nanoparticles exhibit high biocompatibility and low toxicity in mice at Fe<sub>3</sub>O<sub>4</sub> concentrations up to 120 mg/kg when administered via intravenous injection. The Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG nanoparticles enhance the magnetic resonance imaging contrast in cell cultures and tumor-bearing Swiss mice. The autofluorescence of curcumin also allowed us to observe the penetration of the nanoparticles into sarcoma 180 cells. In particular, the nanoconjugates synergistically inhibit the growth of sarcoma 180 tumors via magnetic heating and the anticancer effects of curcumin, both in vitro and in vivo. (4) Conclusions: Our study reveals that Fe<sub>3</sub>O<sub>4</sub>/Cur@ALG has a high potential for medicinal applications and should be further developed for cancer diagnosis and treatment.https://www.mdpi.com/1999-4923/15/5/1523magnetic nanoparticlesMRIhyperthermiacytotoxicitycurcuminsarcoma |
| spellingShingle | Xuan-Hai Do Tu Dac Nguyen Thi Thu Huong Le Thuy Thanh To Thi Van Khanh Bui Nam Hong Pham Khanh Lam Thi My Nhung Hoang Phuong Thu Ha High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Pharmaceutics magnetic nanoparticles MRI hyperthermia cytotoxicity curcumin sarcoma |
| title | High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles |
| title_full | High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles |
| title_fullStr | High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles |
| title_full_unstemmed | High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles |
| title_short | High Biocompatibility, MRI Enhancement, and Dual Chemo- and Thermal-Therapy of Curcumin-Encapsulated Alginate/Fe<sub>3</sub>O<sub>4</sub> Nanoparticles |
| title_sort | high biocompatibility mri enhancement and dual chemo and thermal therapy of curcumin encapsulated alginate fe sub 3 sub o sub 4 sub nanoparticles |
| topic | magnetic nanoparticles MRI hyperthermia cytotoxicity curcumin sarcoma |
| url | https://www.mdpi.com/1999-4923/15/5/1523 |
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