Intestinal parasites infection: protective effect in rheumatoid arthritis?
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated b...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Reumatologia
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| Series: | Revista Brasileira de Reumatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461&lng=en&tlng=en |
| _version_ | 1818823441327849472 |
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| author | Sandra Maximiano de Oliveira Ana Paula Monteiro Gomides Lícia Maria Henrique da Mota Caliandra Maria Bezerra Luna Lima Francisco Airton Castro Rocha |
| author_facet | Sandra Maximiano de Oliveira Ana Paula Monteiro Gomides Lícia Maria Henrique da Mota Caliandra Maria Bezerra Luna Lima Francisco Airton Castro Rocha |
| author_sort | Sandra Maximiano de Oliveira |
| collection | DOAJ |
| description | Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper. |
| first_indexed | 2024-12-18T23:40:02Z |
| format | Article |
| id | doaj.art-ee793d86743a4dcc91754ac03ba32ecb |
| institution | Directory Open Access Journal |
| issn | 1809-4570 |
| language | English |
| last_indexed | 2024-12-18T23:40:02Z |
| publisher | Sociedade Brasileira de Reumatologia |
| record_format | Article |
| series | Revista Brasileira de Reumatologia |
| spelling | doaj.art-ee793d86743a4dcc91754ac03ba32ecb2022-12-21T20:47:25ZengSociedade Brasileira de ReumatologiaRevista Brasileira de Reumatologia1809-457057546146510.1016/j.rbre.2016.06.004S0482-50042017000500461Intestinal parasites infection: protective effect in rheumatoid arthritis?Sandra Maximiano de OliveiraAna Paula Monteiro GomidesLícia Maria Henrique da MotaCaliandra Maria Bezerra Luna LimaFrancisco Airton Castro RochaAbstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461&lng=en&tlng=enRheumatoid arthritisHelminth infectionsImmunomodulation |
| spellingShingle | Sandra Maximiano de Oliveira Ana Paula Monteiro Gomides Lícia Maria Henrique da Mota Caliandra Maria Bezerra Luna Lima Francisco Airton Castro Rocha Intestinal parasites infection: protective effect in rheumatoid arthritis? Revista Brasileira de Reumatologia Rheumatoid arthritis Helminth infections Immunomodulation |
| title | Intestinal parasites infection: protective effect in rheumatoid arthritis? |
| title_full | Intestinal parasites infection: protective effect in rheumatoid arthritis? |
| title_fullStr | Intestinal parasites infection: protective effect in rheumatoid arthritis? |
| title_full_unstemmed | Intestinal parasites infection: protective effect in rheumatoid arthritis? |
| title_short | Intestinal parasites infection: protective effect in rheumatoid arthritis? |
| title_sort | intestinal parasites infection protective effect in rheumatoid arthritis |
| topic | Rheumatoid arthritis Helminth infections Immunomodulation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461&lng=en&tlng=en |
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