miRNA expression profile and involvement of Let-7d-APP in aged rats with isoflurane-induced learning and memory impairment.

miRNA expression profile and involvement of Let-7d-APP in aged rats with isoflurane-induced learning and memory impairment.

MicroRNAs (miRNAs) play a key role in different nervous system diseases. We sought to determine the role of miRNAs in isoflurane-induced learning and memory impairment in aged rats. Male Sprague-Dawley (SD) rats of 18 month were randomly assigned to control group (exposed to mock anesthesia), 2-hour...

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Bibliographic Details
Main Authors: Ting Luo, Shuzhou Yin, Rong Shi, Chengshi Xu, Yun Wang, Jun Cai, Yun Yue, Anshi Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119336

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