Role of Nuclear Receptors in Controlling Erythropoiesis
Nuclear receptors (NRs), are a wide family of ligand-regulated transcription factors sharing a common modular structure composed by an N-terminal domain and a ligand-binding domain connected by a short hinge linker to a DNA-binding domain. NRs are involved in many physiological processes, including...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/5/2800 |
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| author | Valentina Pastori Serena Pozzi Agata Labedz Sajeela Ahmed Antonella Ellena Ronchi |
| author_facet | Valentina Pastori Serena Pozzi Agata Labedz Sajeela Ahmed Antonella Ellena Ronchi |
| author_sort | Valentina Pastori |
| collection | DOAJ |
| description | Nuclear receptors (NRs), are a wide family of ligand-regulated transcription factors sharing a common modular structure composed by an N-terminal domain and a ligand-binding domain connected by a short hinge linker to a DNA-binding domain. NRs are involved in many physiological processes, including metabolism, reproduction and development. Most of them respond to small lipophilic ligands, such as steroids, retinoids, and phospholipids, which act as conformational switches. Some NRs are still “orphan” and the search for their ligands is still ongoing. Upon DNA binding, NRs can act both as transcriptional activators or repressors of their target genes. Theoretically, the possibility to modulate NRs activity with small molecules makes them ideal therapeutic targets, although the complexity of their signaling makes drug design challenging. In this review, we discuss the role of NRs in erythropoiesis, in both homeostatic and stress conditions. This knowledge is important in view of modulating red blood cells production in disease conditions, such as anemias, and for the expansion of erythroid cells in culture for research purposes and for reaching the long-term goal of cultured blood for transfusion. |
| first_indexed | 2024-03-09T20:37:27Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:37:27Z |
| publishDate | 2022-03-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ee7d69800f754aeab71230202f88c4bb2023-11-23T23:09:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01235280010.3390/ijms23052800Role of Nuclear Receptors in Controlling ErythropoiesisValentina Pastori0Serena Pozzi1Agata Labedz2Sajeela Ahmed3Antonella Ellena Ronchi4Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, ItalyDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, ItalyNuclear receptors (NRs), are a wide family of ligand-regulated transcription factors sharing a common modular structure composed by an N-terminal domain and a ligand-binding domain connected by a short hinge linker to a DNA-binding domain. NRs are involved in many physiological processes, including metabolism, reproduction and development. Most of them respond to small lipophilic ligands, such as steroids, retinoids, and phospholipids, which act as conformational switches. Some NRs are still “orphan” and the search for their ligands is still ongoing. Upon DNA binding, NRs can act both as transcriptional activators or repressors of their target genes. Theoretically, the possibility to modulate NRs activity with small molecules makes them ideal therapeutic targets, although the complexity of their signaling makes drug design challenging. In this review, we discuss the role of NRs in erythropoiesis, in both homeostatic and stress conditions. This knowledge is important in view of modulating red blood cells production in disease conditions, such as anemias, and for the expansion of erythroid cells in culture for research purposes and for reaching the long-term goal of cultured blood for transfusion.https://www.mdpi.com/1422-0067/23/5/2800nuclear receptorserythropoiesisstress erythropoiesisglobins genes expression during development |
| spellingShingle | Valentina Pastori Serena Pozzi Agata Labedz Sajeela Ahmed Antonella Ellena Ronchi Role of Nuclear Receptors in Controlling Erythropoiesis International Journal of Molecular Sciences nuclear receptors erythropoiesis stress erythropoiesis globins genes expression during development |
| title | Role of Nuclear Receptors in Controlling Erythropoiesis |
| title_full | Role of Nuclear Receptors in Controlling Erythropoiesis |
| title_fullStr | Role of Nuclear Receptors in Controlling Erythropoiesis |
| title_full_unstemmed | Role of Nuclear Receptors in Controlling Erythropoiesis |
| title_short | Role of Nuclear Receptors in Controlling Erythropoiesis |
| title_sort | role of nuclear receptors in controlling erythropoiesis |
| topic | nuclear receptors erythropoiesis stress erythropoiesis globins genes expression during development |
| url | https://www.mdpi.com/1422-0067/23/5/2800 |
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