Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems.
Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fuel and other organic material shown previously to be neurotoxic.In a prospective cohort study, we evaluated the relationship between Attention Deficit Hyperactivity Disorder behavior problems and prenata...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4221082?pdf=render |
| _version_ | 1819274188019466240 |
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| author | Frederica P Perera Hsin-wen Chang Deliang Tang Emily L Roen Julie Herbstman Amy Margolis Tzu-Jung Huang Rachel L Miller Shuang Wang Virginia Rauh |
| author_facet | Frederica P Perera Hsin-wen Chang Deliang Tang Emily L Roen Julie Herbstman Amy Margolis Tzu-Jung Huang Rachel L Miller Shuang Wang Virginia Rauh |
| author_sort | Frederica P Perera |
| collection | DOAJ |
| description | Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fuel and other organic material shown previously to be neurotoxic.In a prospective cohort study, we evaluated the relationship between Attention Deficit Hyperactivity Disorder behavior problems and prenatal polycyclic aromatic hydrocarbon exposure, adjusting for postnatal exposure.Children of nonsmoking African-American and Dominican women in New York City were followed from in utero to 9 years. Prenatal polycyclic aromatic hydrocarbon exposure was estimated by levels of polycyclic aromatic hydrocarbon- DNA adducts in maternal and cord blood collected at delivery. Postnatal exposure was estimated by the concentration of urinary polycyclic aromatic hydrocarbon metabolites at ages 3 or 5. Attention Deficit Hyperactivity Disorder behavior problems were assessed using the Child Behavior Checklist and the Conners Parent Rating Scale- Revised.High prenatal adduct exposure, measured by elevated maternal adducts was significantly associated with all Conners Parent Rating Scale-Revised subscales when the raw scores were analyzed continuously (N = 233). After dichotomizing at the threshold for moderately to markedly atypical symptoms, high maternal adducts were significantly associated with the Conners Parent Rating Scale-Revised DSM-IV Inattentive (OR = 5.06, 95% CI [1.43, 17.93]) and DSM-IV Total (OR = 3.37, 95% CI [1.10, 10.34]) subscales. High maternal adducts were positivity associated with the DSM-oriented Attention Deficit/Hyperactivity Problems scale on the Child Behavior Checklist, albeit not significant. In the smaller sample with cord adducts, the associations between outcomes and high cord adduct exposure were not statistically significant (N = 162).The results suggest that exposure to polycyclic aromatic hydrocarbons encountered in New York City air may play a role in childhood Attention Deficit Hyperactivity Disorder behavior problems. |
| first_indexed | 2024-12-23T23:04:27Z |
| format | Article |
| id | doaj.art-ee7efd8baae6450990d904dc8d022f5e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:04:27Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ee7efd8baae6450990d904dc8d022f5e2022-12-21T17:26:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11167010.1371/journal.pone.0111670Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems.Frederica P PereraHsin-wen ChangDeliang TangEmily L RoenJulie HerbstmanAmy MargolisTzu-Jung HuangRachel L MillerShuang WangVirginia RauhPolycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fuel and other organic material shown previously to be neurotoxic.In a prospective cohort study, we evaluated the relationship between Attention Deficit Hyperactivity Disorder behavior problems and prenatal polycyclic aromatic hydrocarbon exposure, adjusting for postnatal exposure.Children of nonsmoking African-American and Dominican women in New York City were followed from in utero to 9 years. Prenatal polycyclic aromatic hydrocarbon exposure was estimated by levels of polycyclic aromatic hydrocarbon- DNA adducts in maternal and cord blood collected at delivery. Postnatal exposure was estimated by the concentration of urinary polycyclic aromatic hydrocarbon metabolites at ages 3 or 5. Attention Deficit Hyperactivity Disorder behavior problems were assessed using the Child Behavior Checklist and the Conners Parent Rating Scale- Revised.High prenatal adduct exposure, measured by elevated maternal adducts was significantly associated with all Conners Parent Rating Scale-Revised subscales when the raw scores were analyzed continuously (N = 233). After dichotomizing at the threshold for moderately to markedly atypical symptoms, high maternal adducts were significantly associated with the Conners Parent Rating Scale-Revised DSM-IV Inattentive (OR = 5.06, 95% CI [1.43, 17.93]) and DSM-IV Total (OR = 3.37, 95% CI [1.10, 10.34]) subscales. High maternal adducts were positivity associated with the DSM-oriented Attention Deficit/Hyperactivity Problems scale on the Child Behavior Checklist, albeit not significant. In the smaller sample with cord adducts, the associations between outcomes and high cord adduct exposure were not statistically significant (N = 162).The results suggest that exposure to polycyclic aromatic hydrocarbons encountered in New York City air may play a role in childhood Attention Deficit Hyperactivity Disorder behavior problems.http://europepmc.org/articles/PMC4221082?pdf=render |
| spellingShingle | Frederica P Perera Hsin-wen Chang Deliang Tang Emily L Roen Julie Herbstman Amy Margolis Tzu-Jung Huang Rachel L Miller Shuang Wang Virginia Rauh Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS ONE |
| title | Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. |
| title_full | Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. |
| title_fullStr | Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. |
| title_full_unstemmed | Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. |
| title_short | Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. |
| title_sort | early life exposure to polycyclic aromatic hydrocarbons and adhd behavior problems |
| url | http://europepmc.org/articles/PMC4221082?pdf=render |
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