GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/403 |
| Summary: | Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86) |
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| ISSN: | 1563-0625 2313-741X |