GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/403 |
| _version_ | 1797198125636517888 |
|---|---|
| author | V. V. Petrov N. N. Strambovskaya A. V. Govorin Yu. A. Vitkovsky |
| author_facet | V. V. Petrov N. N. Strambovskaya A. V. Govorin Yu. A. Vitkovsky |
| author_sort | V. V. Petrov |
| collection | DOAJ |
| description | Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86) |
| first_indexed | 2024-03-08T05:51:12Z |
| format | Article |
| id | doaj.art-ee7f80d245bf4416b0d738a0b90b8977 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:53Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-ee7f80d245bf4416b0d738a0b90b89772024-04-22T13:07:36ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01131838610.15789/1563-0625-2011-1-83-86400GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGIONV. V. Petrov0N. N. Strambovskaya1A. V. Govorin2Yu. A. Vitkovsky3ГОУ ВПО «Читинская государственная медицинская академия», г. ЧитаГОУ ВПО «Читинская государственная медицинская академия», г. ЧитаГОУ ВПО «Читинская государственная медицинская академия», г. ЧитаГОУ ВПО «Читинская государственная медицинская академия», г. ЧитаAbstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86)https://www.mimmun.ru/mimmun/article/view/403keywords: cd14tnfαfcgr2agene polymorphisminfluenza а н1n1 |
| spellingShingle | V. V. Petrov N. N. Strambovskaya A. V. Govorin Yu. A. Vitkovsky GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION Медицинская иммунология keywords: cd14 tnfα fcgr2a gene polymorphism influenza а н1n1 |
| title | GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION |
| title_full | GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION |
| title_fullStr | GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION |
| title_full_unstemmed | GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION |
| title_short | GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION |
| title_sort | genetic polymorphisms of cd14 tnfα and fcgr2a in the patients with influenza a h1n1 in transbaikalia region |
| topic | keywords: cd14 tnfα fcgr2a gene polymorphism influenza а н1n1 |
| url | https://www.mimmun.ru/mimmun/article/view/403 |
| work_keys_str_mv | AT vvpetrov geneticpolymorphismsofcd14tnfaandfcgr2ainthepatientswithinfluenzaah1n1intransbaikaliaregion AT nnstrambovskaya geneticpolymorphismsofcd14tnfaandfcgr2ainthepatientswithinfluenzaah1n1intransbaikaliaregion AT avgovorin geneticpolymorphismsofcd14tnfaandfcgr2ainthepatientswithinfluenzaah1n1intransbaikaliaregion AT yuavitkovsky geneticpolymorphismsofcd14tnfaandfcgr2ainthepatientswithinfluenzaah1n1intransbaikaliaregion |