Unfolding the role of autophagy in the cancer metabolism
Autophagy is considered an indispensable process that scavenges toxins, recycles complex macromolecules, and sustains the essential cellular functions. In addition to its housekeeping role, autophagy plays a substantial role in many pathophysiological processes such as cancer. Certainly, it adapts c...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580821002521 |
| _version_ | 1819004057289752576 |
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| author | Anchala Pandey Pooja Yadav Sanjeev Shukla |
| author_facet | Anchala Pandey Pooja Yadav Sanjeev Shukla |
| author_sort | Anchala Pandey |
| collection | DOAJ |
| description | Autophagy is considered an indispensable process that scavenges toxins, recycles complex macromolecules, and sustains the essential cellular functions. In addition to its housekeeping role, autophagy plays a substantial role in many pathophysiological processes such as cancer. Certainly, it adapts cancer cells to thrive in the stress conditions such as hypoxia and starvation. Cancer cells indeed have also evolved by exploiting the autophagy process to fulfill energy requirements through the production of metabolic fuel sources and fundamentally altered metabolic pathways. Occasionally autophagy as a foe impedes tumorigenesis and promotes cell death. The complex role of autophagy in cancer makes it a potent therapeutic target and has been actively tested in clinical trials. Moreover, the versatility of autophagy has opened new avenues of effective combinatorial therapeutic strategies. Thereby, it is imperative to comprehend the specificity of autophagy in cancer-metabolism. This review summarizes the recent research and conceptual framework on the regulation of autophagy by various metabolic pathways, enzymes, and their cross-talk in the cancer milieu, including the implementation of altered metabolism and autophagy in clinically approved and experimental therapeutics. |
| first_indexed | 2024-12-20T23:30:50Z |
| format | Article |
| id | doaj.art-ee7fc403c6e2417cb5449f9b69758d75 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-20T23:30:50Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-ee7fc403c6e2417cb5449f9b69758d752022-12-21T19:23:18ZengElsevierBiochemistry and Biophysics Reports2405-58082021-12-0128101158Unfolding the role of autophagy in the cancer metabolismAnchala Pandey0Pooja Yadav1Sanjeev Shukla2Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, 462066, Madhya Pradesh, IndiaDepartment of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, 462066, Madhya Pradesh, IndiaCorresponding author.; Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, 462066, Madhya Pradesh, IndiaAutophagy is considered an indispensable process that scavenges toxins, recycles complex macromolecules, and sustains the essential cellular functions. In addition to its housekeeping role, autophagy plays a substantial role in many pathophysiological processes such as cancer. Certainly, it adapts cancer cells to thrive in the stress conditions such as hypoxia and starvation. Cancer cells indeed have also evolved by exploiting the autophagy process to fulfill energy requirements through the production of metabolic fuel sources and fundamentally altered metabolic pathways. Occasionally autophagy as a foe impedes tumorigenesis and promotes cell death. The complex role of autophagy in cancer makes it a potent therapeutic target and has been actively tested in clinical trials. Moreover, the versatility of autophagy has opened new avenues of effective combinatorial therapeutic strategies. Thereby, it is imperative to comprehend the specificity of autophagy in cancer-metabolism. This review summarizes the recent research and conceptual framework on the regulation of autophagy by various metabolic pathways, enzymes, and their cross-talk in the cancer milieu, including the implementation of altered metabolism and autophagy in clinically approved and experimental therapeutics.http://www.sciencedirect.com/science/article/pii/S2405580821002521AutophagyMetabolismCancerHypoxiaStarvationTherapeutics |
| spellingShingle | Anchala Pandey Pooja Yadav Sanjeev Shukla Unfolding the role of autophagy in the cancer metabolism Biochemistry and Biophysics Reports Autophagy Metabolism Cancer Hypoxia Starvation Therapeutics |
| title | Unfolding the role of autophagy in the cancer metabolism |
| title_full | Unfolding the role of autophagy in the cancer metabolism |
| title_fullStr | Unfolding the role of autophagy in the cancer metabolism |
| title_full_unstemmed | Unfolding the role of autophagy in the cancer metabolism |
| title_short | Unfolding the role of autophagy in the cancer metabolism |
| title_sort | unfolding the role of autophagy in the cancer metabolism |
| topic | Autophagy Metabolism Cancer Hypoxia Starvation Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2405580821002521 |
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