Dose-response relationships using brain-computer interface technology impact stroke rehabilitation
Brain-computer interfaces (BCI) are an emerging novel technology for stroke rehabilitation. Little is known about how dose-response relationships for BCI therapies affect brain and behavior changes. We report preliminary results on stroke patients (n=16, 11M) with persistent upper extremity motor im...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-06-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00361/full |
| _version_ | 1819052308989739008 |
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| author | Brittany Mei Young Zack eNigogosyan Leo eWalton Alexander eRemsik Jie eSong Veena A Nair Mitchell E Tyler Dorothy Farrar Edwards Kristin eCaldera Justin A Sattin Justin C Williams Vivek ePrabhakaran |
| author_facet | Brittany Mei Young Zack eNigogosyan Leo eWalton Alexander eRemsik Jie eSong Veena A Nair Mitchell E Tyler Dorothy Farrar Edwards Kristin eCaldera Justin A Sattin Justin C Williams Vivek ePrabhakaran |
| author_sort | Brittany Mei Young |
| collection | DOAJ |
| description | Brain-computer interfaces (BCI) are an emerging novel technology for stroke rehabilitation. Little is known about how dose-response relationships for BCI therapies affect brain and behavior changes. We report preliminary results on stroke patients (n=16, 11M) with persistent upper extremity motor impairment who received therapy using a BCI system with functional electrical stimulation of the hand and tongue stimulation. We collected MRI scans and behavioral data using the Action Research Arm Test (ARAT), 9-Hole Peg Test (9-HPT), and Stroke Impact Scale (SIS) before, during, and after the therapy period. Using anatomical and functional MRI, we computed Laterality Index (LI) for brain activity in the motor network during impaired hand finger tapping. Changes from baseline LI and behavioral scores were assessed for relationships with dose, intensity, and frequency of BCI therapy. We found that gains in SIS Strength were directly responsive to BCI therapy: therapy dose and intensity correlated positively with increased SIS Strength (p<0.05), although no direct relationships were identified with ARAT or 9-HPT scores. We found behavioral measures that were not directly sensitive to differences in BCI therapy administration but were associated with concurrent brain changes correlated with BCI therapy administration parameters: therapy dose and intensity showed significant (p<0.05) or trending (0.05<p<0.1) negative correlations with LI changes, while therapy frequency did not affect LI. Reductions in LI were then associated (p<0.05) with increased SIS Activities of Daily Living scores and improved 9-HPT performance. Therefore, some behavioral changes may be reflected by brain changes sensitive to differences in BCI therapy administration, while others such as SIS strength may be directly responsive to BCI therapy administration. Data preliminarily suggest that when using BCI in stroke rehabilitation, therapy frequency may be less important than dose and intensity. |
| first_indexed | 2024-12-21T12:17:47Z |
| format | Article |
| id | doaj.art-ee818d40d13543589037fa9677c937ca |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-21T12:17:47Z |
| publishDate | 2015-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ee818d40d13543589037fa9677c937ca2022-12-21T19:04:23ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-06-01910.3389/fnhum.2015.00361130630Dose-response relationships using brain-computer interface technology impact stroke rehabilitationBrittany Mei Young0Zack eNigogosyan1Leo eWalton2Alexander eRemsik3Jie eSong4Veena A Nair5Mitchell E Tyler6Dorothy Farrar Edwards7Kristin eCaldera8Justin A Sattin9Justin C Williams10Vivek ePrabhakaran11University of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonUniversity of Wisconsin - MadisonBrain-computer interfaces (BCI) are an emerging novel technology for stroke rehabilitation. Little is known about how dose-response relationships for BCI therapies affect brain and behavior changes. We report preliminary results on stroke patients (n=16, 11M) with persistent upper extremity motor impairment who received therapy using a BCI system with functional electrical stimulation of the hand and tongue stimulation. We collected MRI scans and behavioral data using the Action Research Arm Test (ARAT), 9-Hole Peg Test (9-HPT), and Stroke Impact Scale (SIS) before, during, and after the therapy period. Using anatomical and functional MRI, we computed Laterality Index (LI) for brain activity in the motor network during impaired hand finger tapping. Changes from baseline LI and behavioral scores were assessed for relationships with dose, intensity, and frequency of BCI therapy. We found that gains in SIS Strength were directly responsive to BCI therapy: therapy dose and intensity correlated positively with increased SIS Strength (p<0.05), although no direct relationships were identified with ARAT or 9-HPT scores. We found behavioral measures that were not directly sensitive to differences in BCI therapy administration but were associated with concurrent brain changes correlated with BCI therapy administration parameters: therapy dose and intensity showed significant (p<0.05) or trending (0.05<p<0.1) negative correlations with LI changes, while therapy frequency did not affect LI. Reductions in LI were then associated (p<0.05) with increased SIS Activities of Daily Living scores and improved 9-HPT performance. Therefore, some behavioral changes may be reflected by brain changes sensitive to differences in BCI therapy administration, while others such as SIS strength may be directly responsive to BCI therapy administration. Data preliminarily suggest that when using BCI in stroke rehabilitation, therapy frequency may be less important than dose and intensity.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00361/fullfMRIstroke rehabilitationBrain-computer interfacedose-responseBCI TherapyUE motor recovery |
| spellingShingle | Brittany Mei Young Zack eNigogosyan Leo eWalton Alexander eRemsik Jie eSong Veena A Nair Mitchell E Tyler Dorothy Farrar Edwards Kristin eCaldera Justin A Sattin Justin C Williams Vivek ePrabhakaran Dose-response relationships using brain-computer interface technology impact stroke rehabilitation Frontiers in Human Neuroscience fMRI stroke rehabilitation Brain-computer interface dose-response BCI Therapy UE motor recovery |
| title | Dose-response relationships using brain-computer interface technology impact stroke rehabilitation |
| title_full | Dose-response relationships using brain-computer interface technology impact stroke rehabilitation |
| title_fullStr | Dose-response relationships using brain-computer interface technology impact stroke rehabilitation |
| title_full_unstemmed | Dose-response relationships using brain-computer interface technology impact stroke rehabilitation |
| title_short | Dose-response relationships using brain-computer interface technology impact stroke rehabilitation |
| title_sort | dose response relationships using brain computer interface technology impact stroke rehabilitation |
| topic | fMRI stroke rehabilitation Brain-computer interface dose-response BCI Therapy UE motor recovery |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00361/full |
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