Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy
This study aimed to evaluate the effects of the total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy. Sixteen healthy male and female adult hors...
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| Format: | Article |
| Language: | English |
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Sociedade de Medicina Veterinária do Estado do Rio de Janeiro
2022-10-01
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| Series: | Brazilian Journal of Veterinary Medicine |
| Subjects: | |
| Online Access: | https://bjvm.org.br/BJVM/article/view/1267 |
| _version_ | 1797831853676167168 |
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| author | Ubiratan Pereira Melo Maristela Silveira Palhares Cíntia Ferreira Fabiola de Oliveira Paes Leme Valentim Arabicano Gheller |
| author_facet | Ubiratan Pereira Melo Maristela Silveira Palhares Cíntia Ferreira Fabiola de Oliveira Paes Leme Valentim Arabicano Gheller |
| author_sort | Ubiratan Pereira Melo |
| collection | DOAJ |
| description | This study aimed to evaluate the effects of the total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy. Sixteen healthy male and female adult horses of mixed breed, aged between 4 and 14 years, and having a mean body weight of 248.40 ± 2.28 kg and a body score index of 3–4 (scale of 1–5) were divided into four groups with four animals per group. After an adaptation period of 30 days, they were randomly divided into four experimental groups: enteral fluid therapy, enteral fluid therapy associated with glutamine, total parenteral nutrition associated with glutamine, and parenteral fluid therapy. The experiment was further divided into two phases: Phase 1 and Phase 2. In Phase 1, an exploratory laparotomy was performed, treatments were administered to the groups and the horses received no food or water other than those given to their respective groups. In Phase 2, the animals were re-fed. Each phase had a total duration of 144 h. Venous blood samples were collected every 24 h throughout the experimental period for blood gas and electrolyte analyses. The following parameters were evaluated: pH, partial pressure of carbon dioxide, total carbon dioxide, bicarbonate, base shift, anion gap, sodium, potassium, chloride, total calcium and magnesium. Completely randomized designs with a 4 × 7 factorial scheme (groups × harvest time) in Phase 1 and a 4 × 6 factorial scheme (groups × harvest time) in Phase 2 were used with four replications. All values were considered significant when p≤0.05 (95% probability). Blood pH, bicarbonate concentration, and base shift in the PARGL group decreased, indicating metabolic acidosis. Changes in the acid–base and electrolyte balance were more intense in the PARGL group than in the other groups. These results demonstrated the need to monitor blood gas and electrolyte balance in horses with food restriction under nutritional support or prolonged fluid therapy so that such changes are promptly corrected. |
| first_indexed | 2024-04-09T13:58:23Z |
| format | Article |
| id | doaj.art-ee82f80a03054a7590803a4878c1f31e |
| institution | Directory Open Access Journal |
| issn | 0100-2430 2527-2179 |
| language | English |
| last_indexed | 2024-04-09T13:58:23Z |
| publishDate | 2022-10-01 |
| publisher | Sociedade de Medicina Veterinária do Estado do Rio de Janeiro |
| record_format | Article |
| series | Brazilian Journal of Veterinary Medicine |
| spelling | doaj.art-ee82f80a03054a7590803a4878c1f31e2023-05-07T12:41:25ZengSociedade de Medicina Veterinária do Estado do Rio de JaneiroBrazilian Journal of Veterinary Medicine0100-24302527-21792022-10-0144e003222e00322210.29374/2527-2179.bjvm0032221156Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomyUbiratan Pereira Melo0https://orcid.org/0000-0002-1253-2720Maristela Silveira Palhares1Cíntia Ferreira2https://orcid.org/0000-0003-2473-1580Fabiola de Oliveira Paes Leme3https://orcid.org/0000-0002-4013-0147Valentim Arabicano Gheller4https://orcid.org/0000-0002-1983-3104Veterinarian, DSc. Centro Universitário Maurício de Nassau (Uninassau). Campus Natal, RN, Brazil Veterinarian, DSc. Programa de Pós-Graduação em Ciência Animal, Departamento Clínica e Cirurgia Veterinárias. Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG). Campus Pampulha, MG. Brazil.Veterinarian, DSc. Centro Universitário Maurício de Nassau (Uninassau). Campus Natal, RN, Brazil Veterinarian, DSc. Programa de Pós-Graduação em Ciência Animal, Departamento Clínica e Cirurgia Veterinárias. Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG). Campus Pampulha, MG. Brazil.Veterinarian, DSc. Programa de Pós-Graduação em Ciência Animal, Departamento Clínica e Cirurgia Veterinárias. Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG). Campus Pampulha, MG. Brazil.This study aimed to evaluate the effects of the total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy. Sixteen healthy male and female adult horses of mixed breed, aged between 4 and 14 years, and having a mean body weight of 248.40 ± 2.28 kg and a body score index of 3–4 (scale of 1–5) were divided into four groups with four animals per group. After an adaptation period of 30 days, they were randomly divided into four experimental groups: enteral fluid therapy, enteral fluid therapy associated with glutamine, total parenteral nutrition associated with glutamine, and parenteral fluid therapy. The experiment was further divided into two phases: Phase 1 and Phase 2. In Phase 1, an exploratory laparotomy was performed, treatments were administered to the groups and the horses received no food or water other than those given to their respective groups. In Phase 2, the animals were re-fed. Each phase had a total duration of 144 h. Venous blood samples were collected every 24 h throughout the experimental period for blood gas and electrolyte analyses. The following parameters were evaluated: pH, partial pressure of carbon dioxide, total carbon dioxide, bicarbonate, base shift, anion gap, sodium, potassium, chloride, total calcium and magnesium. Completely randomized designs with a 4 × 7 factorial scheme (groups × harvest time) in Phase 1 and a 4 × 6 factorial scheme (groups × harvest time) in Phase 2 were used with four replications. All values were considered significant when p≤0.05 (95% probability). Blood pH, bicarbonate concentration, and base shift in the PARGL group decreased, indicating metabolic acidosis. Changes in the acid–base and electrolyte balance were more intense in the PARGL group than in the other groups. These results demonstrated the need to monitor blood gas and electrolyte balance in horses with food restriction under nutritional support or prolonged fluid therapy so that such changes are promptly corrected.https://bjvm.org.br/BJVM/article/view/1267equine, electrolyte imbalances, fluid therapy, metabolic acidosis, parenteral nutrition. |
| spellingShingle | Ubiratan Pereira Melo Maristela Silveira Palhares Cíntia Ferreira Fabiola de Oliveira Paes Leme Valentim Arabicano Gheller Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy Brazilian Journal of Veterinary Medicine equine, electrolyte imbalances, fluid therapy, metabolic acidosis, parenteral nutrition. |
| title | Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy |
| title_full | Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy |
| title_fullStr | Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy |
| title_full_unstemmed | Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy |
| title_short | Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy |
| title_sort | effects of total parenteral nutrition associated with glutamine enteral fluid therapy with or without glutamine and fluid therapy on the acid base and electrolyte balance of horses starved after exploratory laparotomy |
| topic | equine, electrolyte imbalances, fluid therapy, metabolic acidosis, parenteral nutrition. |
| url | https://bjvm.org.br/BJVM/article/view/1267 |
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