| Summary: | Abstract Objective This study was aimed to asses knowledge of prevention of mother to child transmission of HIV among reproductive age women and associated factors at Mecha district, North West Ethiopia. A community based cross sectional study was conducted among 853 reproductive age women from July 1- 30/2016 in Mecha district. By multistage sampling technique data were collected through pre-tested questionnaire. The collected data was entered in Epi Data 3.1 and analyzed with SPSS version 20. Bivariate and multivariable logistic regression model were used. Result About 22.4% of the respondents were knowledgeable on prevention of mother to child transmission (PMTCT) of HIV. Having knowledge on PMTCT of HIV was significantly associated with urban residence (AOR = 2.486, 95% CI 1.160–5.328), education level of secondary and above (AOR = 5.445, 95% CI 2.698–10.986), those having history of antenatal care followup (AOR = 4.430, 95% CI 1.471–13.340), those with history of institutional delivery (AOR = 4.766, 95%CI 2.004–11.334), those having comprehensive knowledge on HIV/AIDS (AOR = 1.697, 95%CI 1.011–2.846), women who were knowledgeable about mother to child transmission of HIV (AOR = 2.203, 95% CI 1.37–3.54), and women who held discussions with their husband regarding HIV/AIDS, (AOR = 2.700, 95% CI 1.658–4.396).
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