Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report
Background: West Nile virus is an arthropod-borne virus (arbovirus) and emerging cause of significant illness in European and Mediterranean countries. West Nile virus infection can cause severe and potentially fatal neurological illnesses, including encephalitis, meningitis, and acute flaccid paraly...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2019-09-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=2105 |
| _version_ | 1797916119857627136 |
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| author | Barış Arslan Hasan Murat Gündüz Nurdan Ünlü Gökhan Çavuş Dilek Menemenlioğlu |
| author_facet | Barış Arslan Hasan Murat Gündüz Nurdan Ünlü Gökhan Çavuş Dilek Menemenlioğlu |
| author_sort | Barış Arslan |
| collection | DOAJ |
| description | Background: West Nile virus is an arthropod-borne virus (arbovirus) and emerging cause of significant illness in European and Mediterranean countries. West Nile virus infection can cause severe and potentially fatal neurological illnesses, including encephalitis, meningitis, and acute flaccid paralysis. Additionally, immunosuppression, alcohol abuse, old age, and diabetes mellitus are common factors associated with West Nile neuroinvasive disease.
Case Report: In August 2018, a 60-year-old male patient with a history of diffuse large B-cell lymphoma initially presented with symptoms including abdominal pain and distention, nausea, and vomiting. Three days after open abdominal surgery due to adhesive small bowel obstruction, he developed fever, prominent tremors, and rapidly progressing flaccid paralysis. The identification of West Nile virus RNA in the serum sample led to the diagnosis of West Nile neuroinvasive disease.
Conclusion: Clinicians should evaluate patients with acute flaccid paralysis for the evidence of West Nile neuroinvasive disease. It is particularly important for healthcare providers to consider West Nile neuroinvasive disease in the differential diagnosis of aseptic meningitis, encephalitis, and acute paralysis cases, especially in endemic areas. |
| first_indexed | 2024-04-10T12:52:10Z |
| format | Article |
| id | doaj.art-ee83248b96774ac69cc0989b80de31fd |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:52:10Z |
| publishDate | 2019-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-ee83248b96774ac69cc0989b80de31fd2023-02-15T16:13:41ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312019-09-0136528728910.4274/balkanmedj.galenos.2019.2018.12.74Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case ReportBarış Arslan0Hasan Murat Gündüz1Nurdan Ünlü2Gökhan Çavuş3Dilek Menemenlioğlu4Clinic of Anesthesia and Intensive Care, Adana City Training and Research Hospital, Adana, TurkeyDepartment of Anesthesia and Intensive Care, Çukurova University School of Medicine, Adana, TurkeyClinic of Anesthesia and Intensive Care, Adana City Training and Research Hospital, Adana, TurkeyDepartment of Neurosurgery, Adana City Training and Research Hospital, Adana, TurkeyMedical Microbiology Specialist, Public Health General Directorate, Microbiology Reference Laboratories and Biological Products Department, National Arboviruses and Viral Zoonoses Laboratory, Ankara, TurkeyBackground: West Nile virus is an arthropod-borne virus (arbovirus) and emerging cause of significant illness in European and Mediterranean countries. West Nile virus infection can cause severe and potentially fatal neurological illnesses, including encephalitis, meningitis, and acute flaccid paralysis. Additionally, immunosuppression, alcohol abuse, old age, and diabetes mellitus are common factors associated with West Nile neuroinvasive disease. Case Report: In August 2018, a 60-year-old male patient with a history of diffuse large B-cell lymphoma initially presented with symptoms including abdominal pain and distention, nausea, and vomiting. Three days after open abdominal surgery due to adhesive small bowel obstruction, he developed fever, prominent tremors, and rapidly progressing flaccid paralysis. The identification of West Nile virus RNA in the serum sample led to the diagnosis of West Nile neuroinvasive disease. Conclusion: Clinicians should evaluate patients with acute flaccid paralysis for the evidence of West Nile neuroinvasive disease. It is particularly important for healthcare providers to consider West Nile neuroinvasive disease in the differential diagnosis of aseptic meningitis, encephalitis, and acute paralysis cases, especially in endemic areas.http://balkanmedicaljournal.org/text.php?lang=en&id=2105LymhomaTurkeyWest Nile virus |
| spellingShingle | Barış Arslan Hasan Murat Gündüz Nurdan Ünlü Gökhan Çavuş Dilek Menemenlioğlu Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report Balkan Medical Journal Lymhoma Turkey West Nile virus |
| title | Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report |
| title_full | Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report |
| title_fullStr | Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report |
| title_full_unstemmed | Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report |
| title_short | Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report |
| title_sort | neuroinvasive west nile virus disease in an elderly patient with diffuse large b cell lymphoma treated with r chop therapy a case report |
| topic | Lymhoma Turkey West Nile virus |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=2105 |
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