Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study
Abstract Background Professionally applied topical fluoride preparations have been commonly used and have proven to prevent dental decay. Alternative preparations that provide further benefits may be of interest to investigate. This study aimed to investigate the effect of experimental nano silver f...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-022-02271-6 |
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| author | Dina I. El-Desouky Azza Hanno Yasmine Elhamouly Sara A. Hamza Lubna M. El-Desouky Karin M. L. Dowidar |
| author_facet | Dina I. El-Desouky Azza Hanno Yasmine Elhamouly Sara A. Hamza Lubna M. El-Desouky Karin M. L. Dowidar |
| author_sort | Dina I. El-Desouky |
| collection | DOAJ |
| description | Abstract Background Professionally applied topical fluoride preparations have been commonly used and have proven to prevent dental decay. Alternative preparations that provide further benefits may be of interest to investigate. This study aimed to investigate the effect of experimental nano silver fluoride (NSF) formulation compared to commercial sodium fluoride varnish (FV) on prevention of in vitro demineralization of initially sound enamel in primary teeth. Methods Forty-eight extracted/exfoliated sound molars were sectioned buccolingually into 96 specimens then assigned randomly into two equal groups. Each group was further subdivided into two equal subgroups (Ia: NSF, IIa: FV, Ib and IIb as negative controls). The test materials were applied, then all the specimens were subjected to a demineralization pH cycling model for 7 days. Specimens were examined for surface microhardness using Vickers microhardness device and lesion depth was evaluated by polarized light microscope using image J 1.46r software. Data were analyzed using paired t-test, independent t-test, and Mann Whitney U test. Results The test materials were significantly superior to their negative controls, (P < 0.001) and comparable to each other, (P > 0.05) regarding microhardness and lesion depth. In comparison to FV, NSF showed lower yet statistically insignificant percent increase in microhardness and decrease in lesion depth, (P = 0.81, 0.86, respectively). Qualitative evaluation revealed that both agents reduced the lesion depth formation. Conclusion NSF showed similar effect to that of FV in limiting in vitro enamel demineralization caused by acidic challenge. Hence, it could be regarded as a promising alternative preventive agent in primary teeth. |
| first_indexed | 2024-04-13T17:05:38Z |
| format | Article |
| id | doaj.art-ee83342e292b4796b05a4b1f50619c26 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-13T17:05:38Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-ee83342e292b4796b05a4b1f50619c262022-12-22T02:38:29ZengBMCBMC Oral Health1472-68312022-06-0122111010.1186/s12903-022-02271-6Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro studyDina I. El-Desouky0Azza Hanno1Yasmine Elhamouly2Sara A. Hamza3Lubna M. El-Desouky4Karin M. L. Dowidar5Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria UniversityDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria UniversityDepartment of Pediatric and Community Dentistry, Faculty of Dentistry, Pharos University in AlexandriaDepartment of Oral Biology, Faculty of Dentistry, Alexandria UniversityDepartment of Pharmaceutics, Faculty of Pharmacy, Alexandria UniversityDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria UniversityAbstract Background Professionally applied topical fluoride preparations have been commonly used and have proven to prevent dental decay. Alternative preparations that provide further benefits may be of interest to investigate. This study aimed to investigate the effect of experimental nano silver fluoride (NSF) formulation compared to commercial sodium fluoride varnish (FV) on prevention of in vitro demineralization of initially sound enamel in primary teeth. Methods Forty-eight extracted/exfoliated sound molars were sectioned buccolingually into 96 specimens then assigned randomly into two equal groups. Each group was further subdivided into two equal subgroups (Ia: NSF, IIa: FV, Ib and IIb as negative controls). The test materials were applied, then all the specimens were subjected to a demineralization pH cycling model for 7 days. Specimens were examined for surface microhardness using Vickers microhardness device and lesion depth was evaluated by polarized light microscope using image J 1.46r software. Data were analyzed using paired t-test, independent t-test, and Mann Whitney U test. Results The test materials were significantly superior to their negative controls, (P < 0.001) and comparable to each other, (P > 0.05) regarding microhardness and lesion depth. In comparison to FV, NSF showed lower yet statistically insignificant percent increase in microhardness and decrease in lesion depth, (P = 0.81, 0.86, respectively). Qualitative evaluation revealed that both agents reduced the lesion depth formation. Conclusion NSF showed similar effect to that of FV in limiting in vitro enamel demineralization caused by acidic challenge. Hence, it could be regarded as a promising alternative preventive agent in primary teeth.https://doi.org/10.1186/s12903-022-02271-6Artificial cariesEnamel demineralizationFluoride varnishNano silver fluoridePrimary teeth |
| spellingShingle | Dina I. El-Desouky Azza Hanno Yasmine Elhamouly Sara A. Hamza Lubna M. El-Desouky Karin M. L. Dowidar Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study BMC Oral Health Artificial caries Enamel demineralization Fluoride varnish Nano silver fluoride Primary teeth |
| title | Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study |
| title_full | Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study |
| title_fullStr | Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study |
| title_full_unstemmed | Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study |
| title_short | Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study |
| title_sort | preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth in vitro study |
| topic | Artificial caries Enamel demineralization Fluoride varnish Nano silver fluoride Primary teeth |
| url | https://doi.org/10.1186/s12903-022-02271-6 |
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