Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach.
The pandemic amphibian disease chytridiomycosis often exhibits strong seasonality in both prevalence and disease-associated mortality once it becomes endemic. One hypothesis that could explain this temporal pattern is that simple weather-driven pathogen proliferation (population growth) is a major d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3629077?pdf=render |
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| author | Kris A Murray Lee F Skerratt Stephen Garland Darren Kriticos Hamish McCallum |
| author_facet | Kris A Murray Lee F Skerratt Stephen Garland Darren Kriticos Hamish McCallum |
| author_sort | Kris A Murray |
| collection | DOAJ |
| description | The pandemic amphibian disease chytridiomycosis often exhibits strong seasonality in both prevalence and disease-associated mortality once it becomes endemic. One hypothesis that could explain this temporal pattern is that simple weather-driven pathogen proliferation (population growth) is a major driver of chytridiomycosis disease dynamics. Despite various elaborations of this hypothesis in the literature for explaining amphibian declines (e.g., the chytrid thermal-optimum hypothesis) it has not been formally tested on infection patterns in the wild. In this study we developed a simple process-based model to simulate the growth of the pathogen Batrachochytrium dendrobatidis (Bd) under varying weather conditions to provide an a priori test of a weather-linked pathogen proliferation hypothesis for endemic chytridiomycosis. We found strong support for several predictions of the proliferation hypothesis when applied to our model species, Litoria pearsoniana, sampled across multiple sites and years: the weather-driven simulations of pathogen growth potential (represented as a growth index in the 30 days prior to sampling; GI30) were positively related to both the prevalence and intensity of Bd infections, which were themselves strongly and positively correlated. In addition, a machine-learning classifier achieved ~72% success in classifying positive qPCR results when utilising just three informative predictors 1) GI30, 2) frog body size and 3) rain on the day of sampling. Hence, while intrinsic traits of the individuals sampled (species, size, sex) and nuisance sampling variables (rainfall when sampling) influenced infection patterns obtained when sampling via qPCR, our results also strongly suggest that weather-linked pathogen proliferation plays a key role in the infection dynamics of endemic chytridiomycosis in our study system. Predictive applications of the model include surveillance design, outbreak preparedness and response, climate change scenario modelling and the interpretation of historical patterns of amphibian decline. |
| first_indexed | 2024-12-18T11:38:56Z |
| format | Article |
| id | doaj.art-ee83ffb2824d4676aad5b44ca991f18b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T11:38:56Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ee83ffb2824d4676aad5b44ca991f18b2022-12-21T21:09:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6106110.1371/journal.pone.0061061Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach.Kris A MurrayLee F SkerrattStephen GarlandDarren KriticosHamish McCallumThe pandemic amphibian disease chytridiomycosis often exhibits strong seasonality in both prevalence and disease-associated mortality once it becomes endemic. One hypothesis that could explain this temporal pattern is that simple weather-driven pathogen proliferation (population growth) is a major driver of chytridiomycosis disease dynamics. Despite various elaborations of this hypothesis in the literature for explaining amphibian declines (e.g., the chytrid thermal-optimum hypothesis) it has not been formally tested on infection patterns in the wild. In this study we developed a simple process-based model to simulate the growth of the pathogen Batrachochytrium dendrobatidis (Bd) under varying weather conditions to provide an a priori test of a weather-linked pathogen proliferation hypothesis for endemic chytridiomycosis. We found strong support for several predictions of the proliferation hypothesis when applied to our model species, Litoria pearsoniana, sampled across multiple sites and years: the weather-driven simulations of pathogen growth potential (represented as a growth index in the 30 days prior to sampling; GI30) were positively related to both the prevalence and intensity of Bd infections, which were themselves strongly and positively correlated. In addition, a machine-learning classifier achieved ~72% success in classifying positive qPCR results when utilising just three informative predictors 1) GI30, 2) frog body size and 3) rain on the day of sampling. Hence, while intrinsic traits of the individuals sampled (species, size, sex) and nuisance sampling variables (rainfall when sampling) influenced infection patterns obtained when sampling via qPCR, our results also strongly suggest that weather-linked pathogen proliferation plays a key role in the infection dynamics of endemic chytridiomycosis in our study system. Predictive applications of the model include surveillance design, outbreak preparedness and response, climate change scenario modelling and the interpretation of historical patterns of amphibian decline.http://europepmc.org/articles/PMC3629077?pdf=render |
| spellingShingle | Kris A Murray Lee F Skerratt Stephen Garland Darren Kriticos Hamish McCallum Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach. PLoS ONE |
| title | Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach. |
| title_full | Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach. |
| title_fullStr | Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach. |
| title_full_unstemmed | Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach. |
| title_short | Whether the weather drives patterns of endemic amphibian chytridiomycosis: a pathogen proliferation approach. |
| title_sort | whether the weather drives patterns of endemic amphibian chytridiomycosis a pathogen proliferation approach |
| url | http://europepmc.org/articles/PMC3629077?pdf=render |
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