Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex

Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex

Tuberous Sclerosis Complex (TSC) and cortical dysplasia Type IIB (CDIIB) share histopathologic features that suggest similar epileptogenic mechanisms. This study compared the morphological and electrophysiological properties of cortical cells in tissue from pediatric TSC (n=20) and CDIIB (n=20) pati...

Full description

Bibliographic Details
Main Authors:	Carlos Cepeda, Véronique M. André, Jason S. Hauptman, Irene Yamazaki, My N. Huynh, Julia W. Chang, Jane Y. Chen, Robin S. Fisher, Harry V. Vinters, Michael S. Levine, Gary W. Mathern
Format:	Article
Language:	English
Published:	Elsevier 2012-01-01
Series:	Neurobiology of Disease
Subjects:	Tuberous Sclerosis Complex Cortical dysplasia Electrophysiology Synaptic activity Patch clamp recordings
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996111002816

Similar Items

Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex
by: Joyce Zhang, et al.
Published: (2025-01-01)

Focal Cortical Dysplasia Type IIB and Human Papillomavirus
by: J. Gordon Millichap
Published: (2013-03-01)

Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia
by: Carlos Cepeda, et al.
Published: (2014-02-01)

Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients
by: Carlos Cepeda, et al.
Published: (2020-02-01)

Epilepsy Surgery and Tuberous Sclerosis
by: J Gordon Millichap
Published: (1993-09-01)

Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb
by: Gleice K. Sousa, et al.
Published: (2018-12-01)

Patch-clamp analysis : advanced techniques /
by: Walz, Wolfgang
Published: (2007)

Downregulated formyl peptide receptor 2 expression in the epileptogenic foci of patients with focal cortical dysplasia type IIb and tuberous sclerosis complex
by: Kaixuan Huang, et al.
Published: (2022-11-01)

The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy
by: Hannah E. Goldstein, et al.
Published: (2021-02-01)

HCN Channel Modulation of Synaptic Integration in GABAergic Interneurons in Malformed Rat Neocortex
by: John J. Hablitz, et al.
Published: (2017-04-01)

Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice
by: Barbara K. Robens, et al.
Published: (2016-11-01)

Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I<sub>Na</sub> by Lamotrigine; A Potential for Acquired Arrythmias
by: Juan Antonio Contreras Vite, et al.
Published: (2022-09-01)

Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex
by: Viktor Szegedi, et al.
Published: (2020-01-01)

Variability in the Munc13-1 content of excitatory release sites
by: Maria Rita Karlocai, et al.
Published: (2021-04-01)

Firing clamp: A novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances
by: Anton eChizhov, et al.
Published: (2014-03-01)

Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats
by: Roman Vlkolinsky, et al.
Published: (2024-09-01)

The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia
by: Hanna M. Hulshof, et al.
Published: (2021-12-01)

Revised Diagnostic Criteria of Tuberous Sclerosis
by: J Gordon Millichap
Published: (2000-05-01)

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
by: Peter R Strege, et al.
Published: (2023-03-01)

Paroxysmal Discharges in Tissue Slices From Pediatric Epilepsy Surgery Patients: Critical Role of GABAB Receptors in the Generation of Ictal Activity
by: Simon Levinson, et al.
Published: (2020-03-01)

Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex
by: Aniello Lombardi, et al.
Published: (2023-09-01)

Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
by: Omar Babateen, et al.
Published: (2017-12-01)

Simplified Classification of Focal Cortical Dysplasia
by: J Gordon Millichap
Published: (2002-09-01)

Subependymal giant cell astrocytoma as presentation of tuberous sclerosis: a case report
by: P. S. Jayalakshmy, et al.
Published: (2024-01-01)

Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse
by: Paul Jakob Habakuk Hain, et al.
Published: (2024-02-01)

In vivo field recordings effectively monitor the mouse cortex and hippocampus under isoflurane anesthesia
by: Yi-qing Yin, et al.
Published: (2016-01-01)

Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures
by: Vincenzo Giacco, et al.
Published: (2019-06-01)

Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures
by: Julia W. Chang, et al.
Published: (2021-04-01)

The molecular pharmacology and modulation of the proton-activated chloride channel PAC
by: Pearson, CL
Published: (2023)

Alterations of the Hippocampal Networks in Valproic Acid-Induced Rat Autism Model
by: Veronika Bódi, et al.
Published: (2022-02-01)

Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes
by: Feng Cao, et al.
Published: (2017-05-01)

BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses
by: Rossana Rauti, et al.
Published: (2020-03-01)

A subtle case of tuberous sclerosis complex
by: Hitoshi Nakano, et al.
Published: (2015-01-01)

Cardiac rhabdomyomas and cerebral lesions in 4 pediatric patients with tuberous sclerosis
by: Marco Fogante, MD, et al.
Published: (2023-08-01)

A case of tuberous sclerosis complex revealed by epilepsy
by: Imad Bougrine, MD, et al.
Published: (2024-09-01)

Cardiotoxicity of the diamide insecticide chlorantraniliprole in the intact heart and in isolated cardiomyocytes from the honey bee
by: Mahira Kaabeche, et al.
Published: (2024-06-01)

Voltage- and temperature-dependent allosteric modulation of alpha7 nicotinic receptors by PNU120596
by: Fabrio eSitzia, et al.
Published: (2011-12-01)

Oxytocin Increases Phasic and Tonic GABAergic Transmission in CA1 Region of Mouse Hippocampus
by: Claudia Maniezzi, et al.
Published: (2019-05-01)

Generalized Cortical Dysplasia
by: J Gordon Millichap
Published: (1991-08-01)

A transcriptomic and electrophysiological characterisation of the rat stellate ganglia in health and disease
by: Davis, H
Published: (2021)