Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients
Abstract Background To prove the feasibility of integrating CT urography (CTU) into 68Ga-PSMA-11 PET/CT and to analyze the impact of CTU on assigning focal tracer accumulation in the ureteric space to either ureteric excretion or metastatic disease concerning topographic attribution and diagnostic c...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | Cancer Imaging |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40644-017-0132-6 |
| _version_ | 1819116769052196864 |
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| author | Leon Will Frederik L. Giesel Martin T. Freitag Anne K. Berger Walter Mier Klaus Kopka Stefan A. Koerber Hendrik Rathke Christophe Kremer Clemens Kratochwil Hans-Ulrich Kauczor Uwe Haberkorn Tim F. Weber |
| author_facet | Leon Will Frederik L. Giesel Martin T. Freitag Anne K. Berger Walter Mier Klaus Kopka Stefan A. Koerber Hendrik Rathke Christophe Kremer Clemens Kratochwil Hans-Ulrich Kauczor Uwe Haberkorn Tim F. Weber |
| author_sort | Leon Will |
| collection | DOAJ |
| description | Abstract Background To prove the feasibility of integrating CT urography (CTU) into 68Ga-PSMA-11 PET/CT and to analyze the impact of CTU on assigning focal tracer accumulation in the ureteric space to either ureteric excretion or metastatic disease concerning topographic attribution and diagnostic confidence. Methods Ten prostate cancer patients who underwent 68Ga-PSMA-11 PET/CT including CTU because of biochemical relapse or known metastatic disease were retrospectively analyzed. CTU consisted of an excretory phase 10 min after injection of 80 mL iodinated contrast material. Ureter opacification at CTU was evaluated using the following score: 0, 0% opacification; 1, < 50%; 2, 50–99%; 3, 100%. Topographic attribution and confidence of topographic attribution of focal tracer accumulation in the ureteric space were separately assessed for 68Ga-PSMA-11 PET/CT without and with CTU. Diagnostic confidence was evaluated using the following score: 0, < 25% confidence; 1, 26–50%; 2, 51–75%; 3, 76–100%. Results At CTU, mean ureter opacification score was 2.6 ± 0.7. At 68Ga-PSMA-11 PET/CT without CTU, mean confidence of topographic attribution of focal tracer accumulation was 2.5 ± 0.7 in total and 2.6 ± 0.7 for metastatic disease. At 68Ga-PSMA-11 PET/CT with CTU, mean confidence of topographic attribution of focal areas of tracer accumulation was significantly higher with 2.9 ± 0.2 in total and 2.7 ± 0.9 for metastatic disease (p < 0.001). In 4 of 34 findings (12%) attribution to either ureteric excretion or metastatic disease was discrepant between 68Ga-PSMA-11 PET/CT without and with CTU (n.s). Conclusions Integration of CTU into 68Ga-PSMA-11 PET/CT is feasible and increases diagnostic confidence of assigning focal areas of tracer accumulation in the ureteric space to either metastatic disease or ureteric excretion. |
| first_indexed | 2024-12-22T05:22:21Z |
| format | Article |
| id | doaj.art-ee86b57420284b3999a9b2aad8240195 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-22T05:22:21Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-ee86b57420284b3999a9b2aad82401952022-12-21T18:37:42ZengBMCCancer Imaging1470-73302017-12-011711710.1186/s40644-017-0132-6Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patientsLeon Will0Frederik L. Giesel1Martin T. Freitag2Anne K. Berger3Walter Mier4Klaus Kopka5Stefan A. Koerber6Hendrik Rathke7Christophe Kremer8Clemens Kratochwil9Hans-Ulrich Kauczor10Uwe Haberkorn11Tim F. Weber12Department of Nuclear Medicine, Heidelberg University HospitalDepartment of Nuclear Medicine, Heidelberg University HospitalDivision of Radiology, German Cancer Research Center (dkfz)Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University HospitalDepartment of Nuclear Medicine, Heidelberg University HospitalDivision of Radiopharmaceutical Chemistry, German Cancer Research Center (dkfz)Department of Radiation Oncology, Heidelberg University HospitalDepartment of Nuclear Medicine, Heidelberg University HospitalDepartment of Nuclear Medicine, Heidelberg University HospitalDepartment of Nuclear Medicine, Heidelberg University HospitalDepartment of Diagnostic and Interventional Radiology, Heidelberg University HospitalDepartment of Nuclear Medicine, Heidelberg University HospitalDepartment of Diagnostic and Interventional Radiology, Heidelberg University HospitalAbstract Background To prove the feasibility of integrating CT urography (CTU) into 68Ga-PSMA-11 PET/CT and to analyze the impact of CTU on assigning focal tracer accumulation in the ureteric space to either ureteric excretion or metastatic disease concerning topographic attribution and diagnostic confidence. Methods Ten prostate cancer patients who underwent 68Ga-PSMA-11 PET/CT including CTU because of biochemical relapse or known metastatic disease were retrospectively analyzed. CTU consisted of an excretory phase 10 min after injection of 80 mL iodinated contrast material. Ureter opacification at CTU was evaluated using the following score: 0, 0% opacification; 1, < 50%; 2, 50–99%; 3, 100%. Topographic attribution and confidence of topographic attribution of focal tracer accumulation in the ureteric space were separately assessed for 68Ga-PSMA-11 PET/CT without and with CTU. Diagnostic confidence was evaluated using the following score: 0, < 25% confidence; 1, 26–50%; 2, 51–75%; 3, 76–100%. Results At CTU, mean ureter opacification score was 2.6 ± 0.7. At 68Ga-PSMA-11 PET/CT without CTU, mean confidence of topographic attribution of focal tracer accumulation was 2.5 ± 0.7 in total and 2.6 ± 0.7 for metastatic disease. At 68Ga-PSMA-11 PET/CT with CTU, mean confidence of topographic attribution of focal areas of tracer accumulation was significantly higher with 2.9 ± 0.2 in total and 2.7 ± 0.9 for metastatic disease (p < 0.001). In 4 of 34 findings (12%) attribution to either ureteric excretion or metastatic disease was discrepant between 68Ga-PSMA-11 PET/CT without and with CTU (n.s). Conclusions Integration of CTU into 68Ga-PSMA-11 PET/CT is feasible and increases diagnostic confidence of assigning focal areas of tracer accumulation in the ureteric space to either metastatic disease or ureteric excretion.http://link.springer.com/article/10.1186/s40644-017-0132-6PSMAPet/CtCT urographyProstate cancerRenal excretionStaging |
| spellingShingle | Leon Will Frederik L. Giesel Martin T. Freitag Anne K. Berger Walter Mier Klaus Kopka Stefan A. Koerber Hendrik Rathke Christophe Kremer Clemens Kratochwil Hans-Ulrich Kauczor Uwe Haberkorn Tim F. Weber Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients Cancer Imaging PSMA Pet/Ct CT urography Prostate cancer Renal excretion Staging |
| title | Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients |
| title_full | Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients |
| title_fullStr | Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients |
| title_full_unstemmed | Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients |
| title_short | Integration of CT urography improves diagnostic confidence of 68Ga-PSMA-11 PET/CT in prostate cancer patients |
| title_sort | integration of ct urography improves diagnostic confidence of 68ga psma 11 pet ct in prostate cancer patients |
| topic | PSMA Pet/Ct CT urography Prostate cancer Renal excretion Staging |
| url | http://link.springer.com/article/10.1186/s40644-017-0132-6 |
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