Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel?
The differences in diagnosis and management between immune thrombocytopenia (ITP) and leukemia are striking. Leukemia diagnosis and management have evolved substantially over the past 30 years and are now relatively precise. The tendency for leukemic cells to be the overwhelming majority of circulat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAABRON PRESS
2019-08-01
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| Series: | Clinical Hematology International |
| Subjects: | |
| Online Access: | https://www.atlantis-press.com/article/125914914/view |
| _version_ | 1797226795247861760 |
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| author | James Bussel Oriana Miltiadous |
| author_facet | James Bussel Oriana Miltiadous |
| author_sort | James Bussel |
| collection | DOAJ |
| description | The differences in diagnosis and management between immune thrombocytopenia (ITP) and leukemia are striking. Leukemia diagnosis and management have evolved substantially over the past 30 years and are now relatively precise. The tendency for leukemic cells to be the overwhelming majority of circulating and/or bone marrow cells certainly continues to facilitate developments, as does improved molecular assessment. Furthermore, randomized controlled clinical trials of competing regimens in well-defined populations have advanced treatment as well. Currently, ITP diagnosis and management depend very much on the experience and preferences of the hematologist. There are no unequivocally useful molecular tests, no agreement on which testing needs to be performed, and no consensus on treatment. Future studies using advanced techniques would ideally change this over time but, thus far, progress in ITP has been slow. However, the increasing ability to do single-cell DNA and RNA studies and flow cytometric dissection of small populations of cells could radically change the approach to ITP if critical distinctions were uncovered. |
| first_indexed | 2024-04-24T14:30:35Z |
| format | Article |
| id | doaj.art-ee86db179bd14ac4b48136c6f2fd8356 |
| institution | Directory Open Access Journal |
| issn | 2590-0048 |
| language | English |
| last_indexed | 2024-04-24T14:30:35Z |
| publishDate | 2019-08-01 |
| publisher | SAABRON PRESS |
| record_format | Article |
| series | Clinical Hematology International |
| spelling | doaj.art-ee86db179bd14ac4b48136c6f2fd83562024-04-03T03:50:10ZengSAABRON PRESSClinical Hematology International2590-00482019-08-011410.2991/chi.d.190805.001Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel?James BusselOriana MiltiadousThe differences in diagnosis and management between immune thrombocytopenia (ITP) and leukemia are striking. Leukemia diagnosis and management have evolved substantially over the past 30 years and are now relatively precise. The tendency for leukemic cells to be the overwhelming majority of circulating and/or bone marrow cells certainly continues to facilitate developments, as does improved molecular assessment. Furthermore, randomized controlled clinical trials of competing regimens in well-defined populations have advanced treatment as well. Currently, ITP diagnosis and management depend very much on the experience and preferences of the hematologist. There are no unequivocally useful molecular tests, no agreement on which testing needs to be performed, and no consensus on treatment. Future studies using advanced techniques would ideally change this over time but, thus far, progress in ITP has been slow. However, the increasing ability to do single-cell DNA and RNA studies and flow cytometric dissection of small populations of cells could radically change the approach to ITP if critical distinctions were uncovered.https://www.atlantis-press.com/article/125914914/viewLeukemiaPlateletsDiagnosisAutoimmunity |
| spellingShingle | James Bussel Oriana Miltiadous Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel? Clinical Hematology International Leukemia Platelets Diagnosis Autoimmunity |
| title | Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel? |
| title_full | Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel? |
| title_fullStr | Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel? |
| title_full_unstemmed | Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel? |
| title_short | Immune Thrombocytopenia: Are We Stuck in the Mud or Is There Light at the End of the Tunnel? |
| title_sort | immune thrombocytopenia are we stuck in the mud or is there light at the end of the tunnel |
| topic | Leukemia Platelets Diagnosis Autoimmunity |
| url | https://www.atlantis-press.com/article/125914914/view |
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