Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

Here we provide data describing the time-course of blood-glucose and fluid-intake profiles of diabetic hemizygous human-amylin (hA) transgenic mice orally treated with rutin, and matched control mice treated with water. We employed “parametric change-point regression analysis” for investigation of d...

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Main Authors: Jacqueline F. Aitken, Kerry M. Loomes, Isabel Riba-Garcia, Richard D. Unwin, Gordana Prijic, Ashley S. Phillips, Anthony R.J. Phillips, Donghai Wu, Sally D. Poppitt, Ke Ding, Perdita E. Barran, Andrew W. Dowsey, Garth J.S. Cooper
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340916307375
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author Jacqueline F. Aitken
Kerry M. Loomes
Isabel Riba-Garcia
Richard D. Unwin
Gordana Prijic
Ashley S. Phillips
Anthony R.J. Phillips
Donghai Wu
Sally D. Poppitt
Ke Ding
Perdita E. Barran
Andrew W. Dowsey
Garth J.S. Cooper
author_facet Jacqueline F. Aitken
Kerry M. Loomes
Isabel Riba-Garcia
Richard D. Unwin
Gordana Prijic
Ashley S. Phillips
Anthony R.J. Phillips
Donghai Wu
Sally D. Poppitt
Ke Ding
Perdita E. Barran
Andrew W. Dowsey
Garth J.S. Cooper
author_sort Jacqueline F. Aitken
collection DOAJ
description Here we provide data describing the time-course of blood-glucose and fluid-intake profiles of diabetic hemizygous human-amylin (hA) transgenic mice orally treated with rutin, and matched control mice treated with water. We employed “parametric change-point regression analysis” for investigation of differences in time-course profiles between the control and rutin-treatment groups to extract, for each animal, baseline levels of blood glucose and fluid-intake, the change-point time at which blood glucose (diabetes-onset) and fluid-intake (polydipsia-onset) accelerated away from baseline, and the rate of this acceleration. The parametric change-point regression approach applied here allowed a much more accurate determination of the exact time of onset of diabetes than do the standard diagnostic criteria. These data are related to the article entitled “Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice” (J.F. Aitken, K.M. Loomes, I. Riba-Garcia, R.D. Unwin, G. Prijic, A.S. Phillips, A.R.J. Phillips, D. Wu, S.D. Poppitt, K. Ding, P.E. Barran, A.W. Dowsey, G.J.S. Cooper. 2016) [1].
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spelling doaj.art-ee8832a3f4504ef08e14d33f38461e8b2022-12-21T18:53:21ZengElsevierData in Brief2352-34092017-02-0110C29830310.1016/j.dib.2016.11.077Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic miceJacqueline F. Aitken0Kerry M. Loomes1Isabel Riba-Garcia2Richard D. Unwin3Gordana Prijic4Ashley S. Phillips5Anthony R.J. Phillips6Donghai Wu7Sally D. Poppitt8Ke Ding9Perdita E. Barran10Andrew W. Dowsey11Garth J.S. Cooper12School of Biological Sciences, University of Auckland, New ZealandSchool of Biological Sciences, University of Auckland, New ZealandCentre for Advanced Discovery and Experimental Therapeutics, CMFT, Manchester Academic Health Sciences Centre, and Institute of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UKCentre for Advanced Discovery and Experimental Therapeutics, CMFT, Manchester Academic Health Sciences Centre, and Institute of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UKSchool of Biological Sciences, University of Auckland, New ZealandMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, University of Manchester, UKSchool of Biological Sciences, University of Auckland, New ZealandKey Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaSchool of Biological Sciences, University of Auckland, New ZealandCollege of Pharmacy, Jinan University, Guangzhou, ChinaMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, University of Manchester, UKCentre for Advanced Discovery and Experimental Therapeutics, CMFT, Manchester Academic Health Sciences Centre, and Institute of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UKSchool of Biological Sciences, University of Auckland, New ZealandHere we provide data describing the time-course of blood-glucose and fluid-intake profiles of diabetic hemizygous human-amylin (hA) transgenic mice orally treated with rutin, and matched control mice treated with water. We employed “parametric change-point regression analysis” for investigation of differences in time-course profiles between the control and rutin-treatment groups to extract, for each animal, baseline levels of blood glucose and fluid-intake, the change-point time at which blood glucose (diabetes-onset) and fluid-intake (polydipsia-onset) accelerated away from baseline, and the rate of this acceleration. The parametric change-point regression approach applied here allowed a much more accurate determination of the exact time of onset of diabetes than do the standard diagnostic criteria. These data are related to the article entitled “Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice” (J.F. Aitken, K.M. Loomes, I. Riba-Garcia, R.D. Unwin, G. Prijic, A.S. Phillips, A.R.J. Phillips, D. Wu, S.D. Poppitt, K. Ding, P.E. Barran, A.W. Dowsey, G.J.S. Cooper. 2016) [1].http://www.sciencedirect.com/science/article/pii/S2352340916307375
spellingShingle Jacqueline F. Aitken
Kerry M. Loomes
Isabel Riba-Garcia
Richard D. Unwin
Gordana Prijic
Ashley S. Phillips
Anthony R.J. Phillips
Donghai Wu
Sally D. Poppitt
Ke Ding
Perdita E. Barran
Andrew W. Dowsey
Garth J.S. Cooper
Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
Data in Brief
title Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
title_full Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
title_fullStr Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
title_full_unstemmed Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
title_short Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice
title_sort quantitative data describing the impact of the flavonol rutin on in vivo blood glucose and fluid intake profiles and survival of human amylin transgenic mice
url http://www.sciencedirect.com/science/article/pii/S2352340916307375
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