Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China
Background Life's Essential 8 (LE8) metrics for cardiovascular health (CVH) aid primordial prevention in US populations. Methods and Results We conducted a child cohort study (PROC [Beijing Child Growth and Health Cohort]) with baseline (2018–2019) and follow‐up (2020–2021) assessments, enrolli...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.029077 |
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| author | Wen Shu Menglong Li Huidi Xiao Nubiya Amaerjiang Nourhan M. Khattab Jiawulan Zunong Mengying Guan Sten H. Vermund Yifei Hu |
| author_facet | Wen Shu Menglong Li Huidi Xiao Nubiya Amaerjiang Nourhan M. Khattab Jiawulan Zunong Mengying Guan Sten H. Vermund Yifei Hu |
| author_sort | Wen Shu |
| collection | DOAJ |
| description | Background Life's Essential 8 (LE8) metrics for cardiovascular health (CVH) aid primordial prevention in US populations. Methods and Results We conducted a child cohort study (PROC [Beijing Child Growth and Health Cohort]) with baseline (2018–2019) and follow‐up (2020–2021) assessments, enrolling disease‐free 6‐ to 10‐year‐old children from 6 elementary schools in Beijing. We collected LE8‐assessed components via questionnaire surveys and 3 cardiovascular structural parameters by 2‐dimensional M‐mode echocardiography: left ventricular mass (LVM), LVM index, and carotid intima‐media thickness. Compared with 1914 participants (mean age, 6.6 years) at baseline, we saw lower mean CVH scores at follow‐up (n=1789; 8.5 years). Among LE8 components, diet presented the lowest perfect‐score prevalence (5.1%). Only 18.6% of participants had physical activity ≥420 min/wk, 55.9% had nicotine exposure, and 25.2% had abnormal sleep duration. Prevalence of overweight/obesity was 26.8% at baseline and 38.2% at follow‐up. We noted optimal blood lipid scores in 30.7%, while 12.9% of children had abnormal fasting glucose. Normal BP was 71.6% at baseline and 60.3% at follow‐up. LVM (g), LVM index (g/m2.7), and carotid intima‐media thickness (mm) were significantly lower in children with high (56.8, 33.2, 0.35) or moderate CVH scores (60.6, 34.6, 0.36), compared with children with low CVH scores (67.9, 37.1, 0.37). Adjusting for age/sex, LVM (β=11.8 [95% CI, 3.5–20.0]; P=0.005), LVM index (β=4.4 [95% CI, 0.5–8.3]; P=0.027), and carotid intima‐media thickness (β=0.016 [95% CI, 0.002–0.030]; P=0.028) were higher in the low‐CVH group. Conclusions CVH scores were suboptimal, declining with age. LE8 metrics indicated worse CVH in children with abnormal cardiovascular structural measurements, suggesting the validity of LE8 in assessing child CVH. Registration URL: https://www.chictr.org.cn/index.html; Unique identifier: ChiCTR2100044027. |
| first_indexed | 2024-03-13T04:21:18Z |
| format | Article |
| id | doaj.art-ee88eb56ccec484fa6b889f117dd387e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-13T04:21:18Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-ee88eb56ccec484fa6b889f117dd387e2023-06-20T10:12:26ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-06-01121210.1161/JAHA.122.029077Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in ChinaWen Shu0Menglong Li1Huidi Xiao2Nubiya Amaerjiang3Nourhan M. Khattab4Jiawulan Zunong5Mengying Guan6Sten H. Vermund7Yifei Hu8Department of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaDepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaDepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaDepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaDepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaDepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaDepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaYale School of Public Health Yale University New Haven CT USADepartment of Child, Adolescent Health and Maternal Care, School of Public Health Capital Medical University Beijing ChinaBackground Life's Essential 8 (LE8) metrics for cardiovascular health (CVH) aid primordial prevention in US populations. Methods and Results We conducted a child cohort study (PROC [Beijing Child Growth and Health Cohort]) with baseline (2018–2019) and follow‐up (2020–2021) assessments, enrolling disease‐free 6‐ to 10‐year‐old children from 6 elementary schools in Beijing. We collected LE8‐assessed components via questionnaire surveys and 3 cardiovascular structural parameters by 2‐dimensional M‐mode echocardiography: left ventricular mass (LVM), LVM index, and carotid intima‐media thickness. Compared with 1914 participants (mean age, 6.6 years) at baseline, we saw lower mean CVH scores at follow‐up (n=1789; 8.5 years). Among LE8 components, diet presented the lowest perfect‐score prevalence (5.1%). Only 18.6% of participants had physical activity ≥420 min/wk, 55.9% had nicotine exposure, and 25.2% had abnormal sleep duration. Prevalence of overweight/obesity was 26.8% at baseline and 38.2% at follow‐up. We noted optimal blood lipid scores in 30.7%, while 12.9% of children had abnormal fasting glucose. Normal BP was 71.6% at baseline and 60.3% at follow‐up. LVM (g), LVM index (g/m2.7), and carotid intima‐media thickness (mm) were significantly lower in children with high (56.8, 33.2, 0.35) or moderate CVH scores (60.6, 34.6, 0.36), compared with children with low CVH scores (67.9, 37.1, 0.37). Adjusting for age/sex, LVM (β=11.8 [95% CI, 3.5–20.0]; P=0.005), LVM index (β=4.4 [95% CI, 0.5–8.3]; P=0.027), and carotid intima‐media thickness (β=0.016 [95% CI, 0.002–0.030]; P=0.028) were higher in the low‐CVH group. Conclusions CVH scores were suboptimal, declining with age. LE8 metrics indicated worse CVH in children with abnormal cardiovascular structural measurements, suggesting the validity of LE8 in assessing child CVH. Registration URL: https://www.chictr.org.cn/index.html; Unique identifier: ChiCTR2100044027.https://www.ahajournals.org/doi/10.1161/JAHA.122.029077cardiovascular healthchildrencohort studyLife's Essential 8 |
| spellingShingle | Wen Shu Menglong Li Huidi Xiao Nubiya Amaerjiang Nourhan M. Khattab Jiawulan Zunong Mengying Guan Sten H. Vermund Yifei Hu Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular health children cohort study Life's Essential 8 |
| title | Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China |
| title_full | Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China |
| title_fullStr | Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China |
| title_full_unstemmed | Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China |
| title_short | Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China |
| title_sort | validation of life s essential 8 metrics with cardiovascular structural status in children the proc study in china |
| topic | cardiovascular health children cohort study Life's Essential 8 |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.029077 |
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