Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice
Background: The current study is an attempt to register the alterations in the immunological and histological parameters in mice arising from the administration of Dietza maris (D. maris) in order to confirm its protective properties. Materials and Methods: Mice underwent 7 days of treatment with th...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=183;epage=183;aulast=Nofouzi |
| _version_ | 1797649538542993408 |
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| author | Katayoon Nofouzi Gholamreza Hamidian |
| author_facet | Katayoon Nofouzi Gholamreza Hamidian |
| author_sort | Katayoon Nofouzi |
| collection | DOAJ |
| description | Background: The current study is an attempt to register the alterations in the immunological and histological parameters in mice arising from the administration of Dietza maris (D. maris) in order to confirm its protective properties.
Materials and Methods: Mice underwent 7 days of treatment with three doses of D. maris. Then, animals were scrutinized in terms of body weight, relative weight of organs, delayed type of hypersensitivity (DTH) response, and hemagglutination titer (HT). The determination of villus height, villus width, crypt depth, villus/crypt ratio (V/C), Goblet cells, and intestinal epithelial lymphocyte (IEL) density in villi was carried out.
Results: A boosted DTH response was observed as a result of bacteria at medium dose. A variation was noted between the hemagglutinin titer of the control group and that of the high-dose group. Crypt depth, villus width, and villus height manifested alterations. High-dose-treated mice demonstrated proliferation of Goblet cells in the villi, whereas both in medium- and high-dose-treated mice, a distribution of IELs in the villus epithelium was noted. Overall, D. maris showed a stimulatory effect on immune functions in mice. Thus, thanks to improved cellular and humoral immunity and the increased quality of intestine function, we believe that D. maris promises novel therapeutic applications in the future.
Conclusion: The attained findings lend credence to immuno-stimulatory effects arising from the capacity of D. maris to function as immunological adjuvants and to enhance humoral and cellular immunity as well as the intestinal structure and function. |
| first_indexed | 2024-03-11T15:48:32Z |
| format | Article |
| id | doaj.art-ee8958ce16ac4fb9a8430894315b6281 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 |
| language | English |
| last_indexed | 2024-03-11T15:48:32Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-ee8958ce16ac4fb9a8430894315b62812023-10-26T05:43:17ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752023-01-0112118318310.4103/abr.abr_121_22Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in miceKatayoon NofouziGholamreza HamidianBackground: The current study is an attempt to register the alterations in the immunological and histological parameters in mice arising from the administration of Dietza maris (D. maris) in order to confirm its protective properties. Materials and Methods: Mice underwent 7 days of treatment with three doses of D. maris. Then, animals were scrutinized in terms of body weight, relative weight of organs, delayed type of hypersensitivity (DTH) response, and hemagglutination titer (HT). The determination of villus height, villus width, crypt depth, villus/crypt ratio (V/C), Goblet cells, and intestinal epithelial lymphocyte (IEL) density in villi was carried out. Results: A boosted DTH response was observed as a result of bacteria at medium dose. A variation was noted between the hemagglutinin titer of the control group and that of the high-dose group. Crypt depth, villus width, and villus height manifested alterations. High-dose-treated mice demonstrated proliferation of Goblet cells in the villi, whereas both in medium- and high-dose-treated mice, a distribution of IELs in the villus epithelium was noted. Overall, D. maris showed a stimulatory effect on immune functions in mice. Thus, thanks to improved cellular and humoral immunity and the increased quality of intestine function, we believe that D. maris promises novel therapeutic applications in the future. Conclusion: The attained findings lend credence to immuno-stimulatory effects arising from the capacity of D. maris to function as immunological adjuvants and to enhance humoral and cellular immunity as well as the intestinal structure and function.http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=183;epage=183;aulast=Nofouziactinomycetalesdietzia marisimmuno-modulationintestines |
| spellingShingle | Katayoon Nofouzi Gholamreza Hamidian Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice Advanced Biomedical Research actinomycetales dietzia maris immuno-modulation intestines |
| title | Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice |
| title_full | Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice |
| title_fullStr | Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice |
| title_full_unstemmed | Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice |
| title_short | Immuno-modulatory effects of inactivated Dietzia Maris on the selected aspects of cellular and humoral immune responses in mice |
| title_sort | immuno modulatory effects of inactivated dietzia maris on the selected aspects of cellular and humoral immune responses in mice |
| topic | actinomycetales dietzia maris immuno-modulation intestines |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=183;epage=183;aulast=Nofouzi |
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