Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties
AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins—namely CKAMP39, CKAMP52 and CKAMP59—that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/09693 |
| _version_ | 1811236909831159808 |
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| author | Paul Farrow Konstantin Khodosevich Yechiam Sapir Anton Schulmann Muhammad Aslam Yael Stern-Bach Hannah Monyer Jakob von Engelhardt |
| author_facet | Paul Farrow Konstantin Khodosevich Yechiam Sapir Anton Schulmann Muhammad Aslam Yael Stern-Bach Hannah Monyer Jakob von Engelhardt |
| author_sort | Paul Farrow |
| collection | DOAJ |
| description | AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins—namely CKAMP39, CKAMP52 and CKAMP59—that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members. |
| first_indexed | 2024-04-12T12:16:12Z |
| format | Article |
| id | doaj.art-ee89746760c54c8a91168145a329d515 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:16:12Z |
| publishDate | 2015-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ee89746760c54c8a91168145a329d5152022-12-22T03:33:25ZengeLife Sciences Publications LtdeLife2050-084X2015-12-01410.7554/eLife.09693Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor propertiesPaul Farrow0Konstantin Khodosevich1Yechiam Sapir2Anton Schulmann3Muhammad Aslam4Yael Stern-Bach5Hannah Monyer6Jakob von Engelhardt7https://orcid.org/0000-0003-3861-3294Synaptic Signalling and Neurodegeneration, German Cancer Research Center, Heidelberg, Germany; Synaptic Signalling and Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, GermanyDepartment of Clinical Neurobiology, Medical Faculty of Heidelberg University, Heidelberg, Germany; German Cancer Research Center, Heidelberg, GermanyDepartment of Biochemistry and Molecular Biology, Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, IsraelDepartment of Clinical Neurobiology, Medical Faculty of Heidelberg University, Heidelberg, Germany; German Cancer Research Center, Heidelberg, GermanySynaptic Signalling and Neurodegeneration, German Cancer Research Center, Heidelberg, Germany; Synaptic Signalling and Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, GermanyDepartment of Biochemistry and Molecular Biology, Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, IsraelDepartment of Clinical Neurobiology, Medical Faculty of Heidelberg University, Heidelberg, GermanySynaptic Signalling and Neurodegeneration, German Cancer Research Center, Heidelberg, Germany; Synaptic Signalling and Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, GermanyAMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins—namely CKAMP39, CKAMP52 and CKAMP59—that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members.https://elifesciences.org/articles/09693AMPA receptorsauxiliary subunitsdesensitizationdeactivation |
| spellingShingle | Paul Farrow Konstantin Khodosevich Yechiam Sapir Anton Schulmann Muhammad Aslam Yael Stern-Bach Hannah Monyer Jakob von Engelhardt Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties eLife AMPA receptors auxiliary subunits desensitization deactivation |
| title | Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties |
| title_full | Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties |
| title_fullStr | Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties |
| title_full_unstemmed | Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties |
| title_short | Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties |
| title_sort | auxiliary subunits of the ckamp family differentially modulate ampa receptor properties |
| topic | AMPA receptors auxiliary subunits desensitization deactivation |
| url | https://elifesciences.org/articles/09693 |
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